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    Sec31a SEC31 homolog A, COPII coat complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 93646, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sec31aprovided by RGD
    Official Full Name
    SEC31 homolog A, COPII coat complex componentprovided by RGD
    Primary source
    RGD:620233
    See related
    EnsemblRapid:ENSRNOG00000002251 AllianceGenome:RGD:620233
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    VAP1; Sec31l1
    Summary
    Predicted to enable calcium-dependent protein binding activity and structural molecule activity. Predicted to be involved in COPII-coated vesicle cargo loading; endoplasmic reticulum organization; and response to calcium ion. Located in endosome. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to human SEC31A (SEC31 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 158.6), Adrenal (RPKM 139.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sec31a in Genome Data Viewer
    Location:
    14p22
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9518655..9573579)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9214324..9269281)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10854713..10909579)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550950 Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene transfer RNA serine (anticodon AGA) 37 Neighboring gene uncharacterized LOC102551078

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93320

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent protein binding  
    enables calcium-dependent protein binding  
    enables structural molecule activity  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading  
    involved_in COPII-coated vesicle cargo loading  
    involved_in COPII-coated vesicle cargo loading  
    involved_in endoplasmic reticulum organization  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in protein transport  
    involved_in response to calcium ion  
    involved_in response to calcium ion  
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    part_of COPII vesicle coat  
    part_of COPII vesicle coat  
    part_of COPII vesicle coat  
    part_of COPII vesicle coat  
    located_in COPII-coated ER to Golgi transport vesicle  
    located_in COPII-coated ER to Golgi transport vesicle  
    located_in ER to Golgi transport vesicle membrane  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum exit site  
    located_in endoplasmic reticulum exit site  
    located_in endoplasmic reticulum exit site  
    located_in endoplasmic reticulum exit site  
    located_in endoplasmic reticulum membrane  
    located_in endosome PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    part_of vesicle coat  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    protein transport protein Sec31A
    Names
    SEC31 homolog A, COPII coating complex component
    SEC31-like 1
    SEC31-like protein 1
    SEC31-related protein A
    vesicle associated protein
    vesicle-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033021.2NP_148981.2  protein transport protein Sec31A

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      UniProtKB/TrEMBL
      A6K602, G3V699
      Related
      ENSRNOP00000003072.3, ENSRNOT00000003072.7
      Conserved Domains (4) summary
      PHA03247
      Location:7951146
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl29593
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      9518655..9573579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273705.1XP_063129775.1  protein transport protein Sec31A isoform X14

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    2. XM_063273710.1XP_063129780.1  protein transport protein Sec31A isoform X18

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    3. XM_006250677.4XP_006250739.1  protein transport protein Sec31A isoform X1

      See identical proteins and their annotated locations for XP_006250739.1

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    4. XM_063273696.1XP_063129766.1  protein transport protein Sec31A isoform X5

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      UniProtKB/TrEMBL
      A0A0G2K0X9, A6K603
    5. XM_063273698.1XP_063129768.1  protein transport protein Sec31A isoform X8

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    6. XM_063273704.1XP_063129774.1  protein transport protein Sec31A isoform X13

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    7. XM_063273714.1XP_063129784.1  protein transport protein Sec31A isoform X23

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      UniProtKB/TrEMBL
      A0A8L2QIX3
    8. XM_063273703.1XP_063129773.1  protein transport protein Sec31A isoform X12

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    9. XM_063273707.1XP_063129777.1  protein transport protein Sec31A isoform X15

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      UniProtKB/TrEMBL
      A0A8I5ZP55, A6K604
    10. XM_063273711.1XP_063129781.1  protein transport protein Sec31A isoform X19

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    11. XM_063273713.1XP_063129783.1  protein transport protein Sec31A isoform X21

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    12. XM_006250690.4XP_006250752.1  protein transport protein Sec31A isoform X26

      See identical proteins and their annotated locations for XP_006250752.1

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534728
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    13. XM_063273700.1XP_063129770.1  protein transport protein Sec31A isoform X10

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    14. XM_006250678.5XP_006250740.1  protein transport protein Sec31A isoform X2

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    15. XM_006250680.5XP_006250742.1  protein transport protein Sec31A isoform X4

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    16. XM_006250687.5XP_006250749.1  protein transport protein Sec31A isoform X22

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    17. XM_006250681.5XP_006250743.1  protein transport protein Sec31A isoform X5

      See identical proteins and their annotated locations for XP_006250743.1

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      UniProtKB/TrEMBL
      A0A0G2K0X9, A6K603
      Related
      ENSRNOP00000071621.2, ENSRNOT00000091367.3
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    18. XM_006250683.5XP_006250745.1  protein transport protein Sec31A isoform X8

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Related
      ENSRNOP00000038196.6, ENSRNOT00000033489.7
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    19. XM_063273699.1XP_063129769.1  protein transport protein Sec31A isoform X9

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    20. XM_006250684.5XP_006250746.1  protein transport protein Sec31A isoform X13

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    21. XM_006250688.5XP_006250750.1  protein transport protein Sec31A isoform X23

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      UniProtKB/TrEMBL
      A0A8L2QIX3
      Related
      ENSRNOP00000109931.1, ENSRNOT00000153513.1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573767
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    22. XM_006250679.5XP_006250741.1  protein transport protein Sec31A isoform X3

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:547741
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    23. XM_063273697.1XP_063129767.1  protein transport protein Sec31A isoform X6

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    24. XM_063273702.1XP_063129772.1  protein transport protein Sec31A isoform X12

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Related
      ENSRNOP00000079808.2, ENSRNOT00000097169.2
    25. XM_063273706.1XP_063129776.1  protein transport protein Sec31A isoform X15

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      UniProtKB/TrEMBL
      A0A8I5ZP55, A6K604
    26. XM_063273709.1XP_063129779.1  protein transport protein Sec31A isoform X17

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    27. XM_063273712.1XP_063129782.1  protein transport protein Sec31A isoform X20

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    28. XM_039092523.2XP_038948451.1  protein transport protein Sec31A isoform X25

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (3) summary
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl14807
      Location:547741
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl29593
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    29. XM_006250682.5XP_006250744.1  protein transport protein Sec31A isoform X7

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534728
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    30. XM_063273701.1XP_063129771.1  protein transport protein Sec31A isoform X11

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    31. XM_063273715.1XP_063129785.1  protein transport protein Sec31A isoform X24

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
    32. XM_063273708.1XP_063129778.1  protein transport protein Sec31A isoform X16

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      UniProtKB/TrEMBL
      A0A8I6GED0
      Related
      ENSRNOP00000085826.1, ENSRNOT00000116260.2
    33. XM_006250685.5XP_006250747.1  protein transport protein Sec31A isoform X19

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534728
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    34. XM_006250686.5XP_006250748.1  protein transport protein Sec31A isoform X21

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534728
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    35. XM_006250689.5XP_006250751.1  protein transport protein Sec31A isoform X26

      See identical proteins and their annotated locations for XP_006250751.1

      UniProtKB/Swiss-Prot
      Q5RKK4, Q9Z2Q1
      Conserved Domains (4) summary
      COG2319
      Location:31405
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534728
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
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