U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Itgam integrin subunit alpha M [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25021, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itgamprovided by RGD
    Official Full Name
    integrin subunit alpha Mprovided by RGD
    Primary source
    RGD:2926
    See related
    EnsemblRapid:ENSRNOG00000019728 AllianceGenome:RGD:2926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd11b
    Summary
    Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to contribute to cargo receptor activity. Involved in several processes, including response to Gram-positive bacterium; response to curcumin; and response to ischemia. Located in cell surface. Used to study mesangial proliferative glomerulonephritis; neutropenia; and transient cerebral ischemia. Biomarker of brain ischemia; diabetic retinopathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in lupus nephritis; persistent fetal circulation syndrome; and pre-eclampsia. Orthologous to human ITGAM (integrin subunit alpha M). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 91.9), Lung (RPKM 59.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itgam in Genome Data Viewer
    Location:
    1q37
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192089496..192139947)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182659047..182709501)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199495312..199545738)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556135 Neighboring gene RNA, U1 small nuclear 140 Neighboring gene integrin subunit alpha X Neighboring gene integrin subunit alpha D

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to cargo receptor activity  
    enables cargo receptor activity  
    enables complement component C3b binding  
    enables heat shock protein binding  
    enables heparan sulfate proteoglycan binding  
    enables heparin binding  
    enables metal ion binding  
    enables opsonin binding  
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    acts_upstream_of_or_within activated T cell proliferation  
    involved_in amyloid-beta clearance  
    acts_upstream_of_or_within cell adhesion  
    acts_upstream_of_or_within cell-cell adhesion  
    involved_in cell-matrix adhesion  
    acts_upstream_of_or_within cellular extravasation  
    involved_in complement receptor mediated signaling pathway  
    involved_in complement-mediated synapse pruning  
    involved_in ectodermal cell differentiation  
    involved_in forebrain development  
    involved_in heterotypic cell-cell adhesion PubMed 
    involved_in integrin-mediated signaling pathway  
    involved_in leukocyte adhesion to vascular endothelial cell  
    acts_upstream_of_or_within leukocyte cell-cell adhesion  
    acts_upstream_of_or_within leukocyte migration involved in inflammatory response  
    acts_upstream_of_or_within microglia development  
    involved_in microglial cell activation  
    involved_in negative regulation of dopamine metabolic process  
    involved_in neutrophil apoptotic process  
    acts_upstream_of_or_within neutrophil chemotaxis  
    involved_in phagocytosis  
    involved_in phagocytosis, engulfment  
    involved_in positive regulation of mast cell differentiation  
    involved_in positive regulation of microglial cell mediated cytotoxicity  
    involved_in positive regulation of neutrophil degranulation  
    involved_in positive regulation of prostaglandin-E synthase activity  
    involved_in positive regulation of protein targeting to membrane  
    involved_in positive regulation of superoxide anion generation  
    involved_in receptor-mediated endocytosis  
    involved_in response to Gram-positive bacterium PubMed 
    involved_in response to curcumin PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to ischemia PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in vertebrate eye-specific patterning  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in cell surface  
    located_in external side of plasma membrane  
    located_in extracellular space  
    part_of integrin alphaM-beta2 complex  
    located_in membrane  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane raft  

    General protein information

    Preferred Names
    integrin alpha-M
    Names
    integrin, alpha M

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012711.2NP_036843.2  integrin alpha-M precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K4L8, A6I9Y2, G3V8L7
      Related
      ENSRNOP00000026748.5, ENSRNOT00000026748.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      192089496..192139947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230214.5XP_006230276.1  integrin alpha-M isoform X1

      UniProtKB/TrEMBL
      G3V8L7
      Related
      ENSRNOP00000073093.3, ENSRNOT00000086003.3
      Conserved Domains (4) summary
      smart00191
      Location:517570
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11291141
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:6151032
      Integrin_alpha2; Integrin alpha
    External link. Please review our privacy policy.