U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ces2a carboxylesterase 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246252, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    Ces2aprovided by RGD
    Official Full Name
    carboxylesterase 2Aprovided by RGD
    Primary source
    RGD:708353
    See related
    EnsemblRapid:ENSRNOG00000011330 AllianceGenome:RGD:708353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ces6
    Summary
    Enables carboxylesterase activity and retinyl-palmitate esterase activity. Predicted to be involved in retinol metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Restricted expression toward (RPKM 625.6) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ces2a in Genome Data Viewer
    Location:
    19p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (135885..142935, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (129428..136480, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (59110..64378, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxyesterase 2B Neighboring gene carboxylesterase 2C, pseudogene 2 Neighboring gene carboxylesterase 2E Neighboring gene uncharacterized LOC120098497 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene. Liu J, et al. Mol Pharmacol, 2021 Nov. PMID 34503976
    2. Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases. Holmes RS, et al. J Med Primatol, 2009 Feb. PMID 19187434, Free PMC Article
    3. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, et al. Eur J Biochem, 2002 Sep. PMID 12230550
    4. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene.
      Title: Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinyl-palmitate esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables trans-permethrin hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pyrethroid hydrolase Ces2a
    Names
    carboxylesterase 6
    carboxylesterase isoenzyme
    carboxylic ester hydrolase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144743.1 → NP_653344.1  pyrethroid hydrolase Ces2a precursor

      See identical proteins and their annotated locations for NP_653344.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) represents the functional allele that is not present in some strains, including the strain of the reference genome.
      Source sequence(s)
      AY034877
      UniProtKB/Swiss-Prot
      F7F3M3, Q8K3R0
      UniProtKB/TrEMBL
      A0A0G2K1L3
      Conserved Domains (1) summary
      pfam00135
      Location:30 → 537
      COesterase; Carboxylesterase family

    RNA

    1. NR_171898.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) contains a premature stop codon, and represents the non-functional allele present in some strains, including the strain of the reference genome. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, coding, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000019
      Related
      ENSRNOT00000015451.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      135885..142935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3R0.1 GenPept UniProtKB/Swiss-Prot:Q8K3R0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools