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    Ldhc lactate dehydrogenase C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29634, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ldhcprovided by RGD
    Official Full Name
    lactate dehydrogenase Cprovided by RGD
    Primary source
    RGD:69366
    See related
    EnsemblRapid:ENSRNOG00000013103 AllianceGenome:RGD:69366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ldh3
    Summary
    Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate catabolic process. Predicted to act upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate biosynthetic process from pyruvate. Predicted to be located in cytoplasm and motile cilium. Predicted to be active in cytosol and mitochondrion. Orthologous to human LDHC (lactate dehydrogenase C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1668.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ldhc in Genome Data Viewer
    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (106522140..106539649)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (97385984..97403382)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102914875..102931843)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene general transcription factor IIH subunit 1 Neighboring gene uncharacterized LOC102552634 Neighboring gene uncharacterized LOC120099812 Neighboring gene lactate dehydrogenase A Neighboring gene tumor susceptibility 101 Neighboring gene UEV and lactate/malate dehyrogenase domains

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility. Odet F, et al. Biol Reprod, 2008 Jul. PMID 18367675, Free PMC Article
    2. Amino acid sequence studies on lactate dehydrogenase C4 isozymes from mouse and rat testes. Pan YC, et al. J Biol Chem, 1983 Jun 10. PMID 6343385
    3. Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Read JA, et al. Proteins, 2001 May 1. PMID 11276087
    4. Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat. Tsuji S, et al. Proc Natl Acad Sci U S A, 1994 Sep 27. PMID 7937776, Free PMC Article
    5. Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli. LeVan KM, et al. Biochem J, 1991 Feb 1. PMID 1996957, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-lactate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactate biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lactate biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyruvate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    L-lactate dehydrogenase C chain
    Names
    LDH testis subunit
    LDH-C
    LDH-X
    lactate dehydrogenase 3, C chain, sperm specific
    NP_058962.2
    XP_006229295.1
    XP_008757566.1
    XP_017444552.1
    XP_038965574.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017266.2 → NP_058962.2  L-lactate dehydrogenase C chain

      See identical proteins and their annotated locations for NP_058962.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078862
      UniProtKB/Swiss-Prot
      P19629
      UniProtKB/TrEMBL
      A6JBD6, F7FDE8, Q6AYX2
      Related
      ENSRNOP00000017851.3, ENSRNOT00000017851.8
      Conserved Domains (1) summary
      cd05293
      Location:18 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      106522140..106539649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109646.2 → XP_038965574.2  L-lactate dehydrogenase C chain isoform X1

      UniProtKB/Swiss-Prot
      P19629

    2. XM_008759344.4 → XP_008757566.1  L-lactate dehydrogenase C chain isoform X2

      UniProtKB/Swiss-Prot
      P19629
      Conserved Domains (2) summary
      cd05293
      Location:22 → 333
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:29 → 329
      L-LDH-NAD; L-lactate dehydrogenase

    3. XM_006229233.5 → XP_006229295.1  L-lactate dehydrogenase C chain isoform X3

      See identical proteins and their annotated locations for XP_006229295.1

      UniProtKB/Swiss-Prot
      P19629
      UniProtKB/TrEMBL
      A6JBD6, F7FDE8, Q6AYX2
      Related
      ENSRNOP00000071562.3, ENSRNOT00000082718.3
      Conserved Domains (1) summary
      cd05293
      Location:18 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    4. XM_017589063.3 → XP_017444552.1  L-lactate dehydrogenase C chain isoform X4

      UniProtKB/Swiss-Prot
      P19629
      Related
      ENSRNOP00000075021.2, ENSRNOT00000090520.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19629.3 GenPept UniProtKB/Swiss-Prot:P19629

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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