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    Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79130, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnajc5provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C5provided by RGD
    Primary source
    RGD:620516
    See related
    EnsemblRapid:ENSRNOG00000015202 AllianceGenome:RGD:620516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Csp
    Summary
    Enables ATP-dependent protein binding activity. Predicted to be involved in chaperone-mediated protein folding and regulation of synaptic vesicle cycle. Predicted to act upstream of or within negative regulation of neuron apoptotic process. Located in terminal bouton. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4. Orthologous to human DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 594.8), Thymus (RPKM 269.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnajc5 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188999508..189033455)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168621905..168656570)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177012714..177047787)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548047 Neighboring gene abhydrolase domain containing 16B Neighboring gene TPD52 like 2 Neighboring gene ribosomal protein L34-like2 Neighboring gene uridine-cytidine kinase 1-like 1 Neighboring gene zinc finger protein 512B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP-dependent protein binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in chromaffin granule membrane  
    located_in cytosol  
    located_in cytosol  
    is_active_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in melanosome  
    is_active_in membrane  
    located_in membrane  
    is_active_in neuromuscular junction  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynapse  
    is_active_in presynapse  
    located_in synaptic vesicle  
    is_active_in synaptic vesicle membrane PubMed 
    located_in terminal bouton PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 5
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 5
    cysteine string protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431433.1NP_001418362.1  dnaJ homolog subfamily C member 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P60905
      UniProtKB/TrEMBL
      A0A8I6A9F3, A6KLZ8
    2. NM_001431434.1NP_001418363.1  dnaJ homolog subfamily C member 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P60905
      UniProtKB/TrEMBL
      A0A8I6A9F3, A6KLZ8
    3. NM_001431435.1NP_001418364.1  dnaJ homolog subfamily C member 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P60905
      UniProtKB/TrEMBL
      A0A8I6A9F3, A6KLZ8
    4. NM_024161.4NP_077075.1  dnaJ homolog subfamily C member 5

      See identical proteins and their annotated locations for NP_077075.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P60905
      UniProtKB/TrEMBL
      A0A8I6A9F3, A6KLZ8
      Conserved Domains (1) summary
      COG0484
      Location:1584
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_197211.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    2. NR_197212.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    3. NR_197213.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    4. NR_197214.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188999508..189033455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762544.4XP_008760766.1  dnaJ homolog subfamily C member 5 isoform X1

      Conserved Domains (1) summary
      COG0484
      Location:1584
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    2. XM_008762545.4XP_008760767.1  dnaJ homolog subfamily C member 5 isoform X1

      Related
      ENSRNOP00000078729.2, ENSRNOT00000102827.2
      Conserved Domains (1) summary
      COG0484
      Location:1584
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. XR_352967.5 RNA Sequence

    2. XR_352968.5 RNA Sequence

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