U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Nmbr neuromedin B receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25264, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    Nmbrprovided by RGD
    Full Name
    neuromedin B receptorprovided by RGD
    Primary source
    RGD:3181
    See related
    EnsemblRapid:ENSRNOG00000012103 AllianceGenome:RGD:3181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NMB-R
    Summary
    Enables neuropeptide receptor activity. Predicted to be involved in several processes, including antiviral innate immune response; positive regulation of osteoclast proliferation; and regulation of cytokine production. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human NMBR (neuromedin B receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 15.9), Kidney (RPKM 5.6) and 2 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nmbr in Genome Data Viewer
    Location:
    1p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (10942476..10966174)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (9115033..9146081)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (8933744..8945850)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690921 Neighboring gene vesicle trafficking 1 Neighboring gene gap junction protein, epsilon 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102552144

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor. Wada E, et al. Neuron, 1991 Mar. PMID 1848080
    2. Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. Giladi E, et al. J Mol Neurosci, 1993 Spring. PMID 8391296
    3. The peptidergic control circuit for sighing. Li P, et al. Nature, 2016 Feb 18. PMID 26855425, Free PMC Article
    4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bombesin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antiviral innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antiviral innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in bombesin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interferon-alpha production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoclast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of osteoclast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoclast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of respiratory gaseous exchange IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of respiratory gaseous exchange ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of respiratory gaseous exchange ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sneeze reflex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sneeze reflex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sneeze reflex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    neuromedin-B receptor
    Names
    neuromedin-B-preferring bombesin receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012799.2 → NP_036931.1  neuromedin-B receptor

      See identical proteins and their annotated locations for NP_036931.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P24053
      UniProtKB/TrEMBL
      A6JP76
      Related
      ENSRNOP00000016215.7, ENSRNOT00000016215.8
      Conserved Domains (2) summary
      cd14964
      Location:45 → 71
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:44 → 335
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      10942476..10966174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101531.2 → XP_038957459.1  neuromedin-B receptor isoform X1

      UniProtKB/Swiss-Prot
      P24053
      UniProtKB/TrEMBL
      A6JP76
      Conserved Domains (2) summary
      cd14964
      Location:45 → 71
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:44 → 335
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_063281563.1 → XP_063137633.1  neuromedin-B receptor isoform X1

      UniProtKB/Swiss-Prot
      P24053
      UniProtKB/TrEMBL
      A6JP76
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24053.1 GenPept UniProtKB/Swiss-Prot:P24053

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Miscellaneous