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    Msi1 musashi RNA-binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msi1provided by RGD
    Official Full Name
    musashi RNA-binding protein 1provided by RGD
    Primary source
    RGD:628778
    See related
    EnsemblRapid:ENSRNOG00000001156 AllianceGenome:RGD:628778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Msi1h
    Summary
    Predicted to enable identical protein binding activity; mRNA binding activity; and poly(U) RNA binding activity. Involved in epithelial cell differentiation and response to hormone. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Biomarker of brain infarction and brain ischemia. Orthologous to human MSI1 (musashi RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 48.8), Adrenal (RPKM 47.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msi1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46815225..46911852, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41158301..41251134, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (46899835..46935335, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene sirtuin 4 Neighboring gene phospholipase A2 group IB Neighboring gene uncharacterized LOC134481302 Neighboring gene uncharacterized LOC102547958 Neighboring gene transmembrane protein 258, pseudogene 2 Neighboring gene cytochrome c oxidase subunit 6A1 Neighboring gene TP53 regulated inhibitor of apoptosis 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of Musashi-1 Increases in Bone Healing. Padial-Molina M, et al. Int J Mol Sci, 2021 Mar 26. PMID 33810326, Free PMC Article
    2. Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution. Nagata H, et al. FEBS Lett, 2006 Jan 9. PMID 16360154
    3. Proliferation and differentiation of neural stem cells in adult rats after cerebral infarction. Zhang B, et al. Chin Med Sci J, 2004 Jun. PMID 15250238
    4. Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia. Yagita Y, et al. J Neurosci Res, 2002 Sep 15. PMID 12205668
    5. Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein musashi-1. Cuadrado A, et al. Mol Cell Neurosci, 2002 Jun. PMID 12093154

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
      Title: Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
    2. Expression of Musashi-1 Increases in Bone Healing.
      Title: Expression of Musashi-1 Increases in Bone Healing.
    3. data suggest that in response to environmental cues that oppose cell cycle progression, regulation of Musashi function is required to promote target mRNA translation and cell fate transition
      Title: Neural stem and progenitor cell fate transition requires regulation of Musashi1 function.
    4. Results do not support MSI-1 as a putative neoplastic stem cell marker in colonic tumors co-expressing nuclear beta-catenin.
      Title: Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin.
    5. Nestin and Musashi1 as the markers of neural stem cells in rat telencephalon following transitory focal ischemia
      Title: [Nestin and Musashi1 as the markers of neural stem cells in rat telencephalon following transitory focal ischemia].
    6. neuronal progenitor cells in the SGZ expressed Msi1 but not nestin.
      Title: Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular condensate scaffold activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(U) RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hormone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein Musashi homolog 1
    Names
    Musashi homolog 1(Drosophila)
    musashi-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148890.2 → NP_683688.1  RNA-binding protein Musashi homolog 1

      See identical proteins and their annotated locations for NP_683688.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q8K3P4
      UniProtKB/TrEMBL
      A6J1U2, F1LRH1
      Related
      ENSRNOP00000001532.6, ENSRNOT00000001532.8
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 339
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:21 → 96
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      46815225..46911852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271088.1 → XP_063127158.1  RNA-binding protein Musashi homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8K3P4
      UniProtKB/TrEMBL
      A6J1U2, F1LRH1

    2. XM_039089125.2 → XP_038945053.1  RNA-binding protein Musashi homolog 1 isoform X7

      UniProtKB/TrEMBL
      A6J1U2, F1LRH1
      Conserved Domains (2) summary
      TIGR01628
      Location:8 → 236
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:7 → 80
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    3. XM_039089122.2 → XP_038945050.1  RNA-binding protein Musashi homolog 1 isoform X4

      UniProtKB/TrEMBL
      A6J1U2, F1LRH1
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 329
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:21 → 96
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    4. XM_039089121.2 → XP_038945049.1  RNA-binding protein Musashi homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GAA4, A6J1U2, F1LRH1
      Related
      ENSRNOP00000084373.1, ENSRNOT00000117406.3
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 320
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:21 → 96
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    5. XM_039089120.2 → XP_038945048.1  RNA-binding protein Musashi homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6J1U2, F1LRH1
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 328
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:21 → 96
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    6. XM_039089123.2 → XP_038945051.1  RNA-binding protein Musashi homolog 1 isoform X5

      UniProtKB/TrEMBL
      A6J1U2, F1LRH1
      Conserved Domains (2) summary
      TIGR01628
      Location:54 → 295
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:66 → 139
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    7. XM_063271091.1 → XP_063127161.1  RNA-binding protein Musashi homolog 1 isoform X9

    8. XM_063271090.1 → XP_063127160.1  RNA-binding protein Musashi homolog 1 isoform X8

    9. XM_039089124.2 → XP_038945052.1  RNA-binding protein Musashi homolog 1 isoform X6

      Conserved Domains (2) summary
      TIGR01628
      Location:37 → 241
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:36 → 85
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_010056364.1 RNA Sequence

    2. XR_010056363.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3P4.1 GenPept UniProtKB/Swiss-Prot:Q8K3P4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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