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    Becn1 beclin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114558, updated on 9-Dec-2024

    Summary

    Official Symbol
    Becn1provided by RGD
    Official Full Name
    beclin 1provided by RGD
    Primary source
    RGD:620190
    See related
    EnsemblRapid:ENSRNOG00000020513 AllianceGenome:RGD:620190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Beclin1
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in several processes, including intracellular signaling cassette; regulation of apoptotic process; and regulation of organelle organization. Located in dendrite and trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 276.8), Thymus (RPKM 266.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Becn1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86731649..86747002, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86231387..86246742, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89209944..89225297, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene ATP synthase membrane subunit K, pseudogene 2 Neighboring gene cytochrome C oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene proteasome activator subunit 3 Neighboring gene amine oxidase, copper containing 2, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding  
    enables identical protein binding  
    enables molecular adaptor activity  
    enables phosphatidylinositol 3-kinase binding  
    enables phosphatidylinositol 3-kinase binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    enables ubiquitin protein ligase binding PubMed 
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 72
    Process Evidence Code Pubs
    involved_in JNK cascade PubMed 
    involved_in SMAD protein signal transduction PubMed 
    acts_upstream_of_or_within amyloid-beta metabolic process  
    involved_in apoptotic process  
    involved_in autophagosome assembly  
    involved_in autophagosome assembly PubMed 
    involved_in autophagosome assembly  
    involved_in autophagosome assembly  
    involved_in autophagosome maturation  
    involved_in autophagy  
    involved_in autophagy PubMed 
    acts_upstream_of_or_within autophagy  
    involved_in autophagy  
    involved_in autophagy  
    involved_in cell division  
    involved_in cellular response to aluminum ion PubMed 
    involved_in cellular response to amino acid starvation PubMed 
    involved_in cellular response to copper ion PubMed 
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to glucose starvation  
    involved_in cellular response to glucose starvation  
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to nitrogen starvation  
    involved_in cellular response to oxygen-glucose deprivation PubMed 
    involved_in circadian rhythm PubMed 
    involved_in cytoplasmic pattern recognition receptor signaling pathway  
    involved_in defense response to virus  
    involved_in early endosome to late endosome transport  
    involved_in early endosome to late endosome transport  
    involved_in engulfment of apoptotic cell  
    involved_in late endosome to vacuole transport  
    acts_upstream_of_or_within lysosome organization  
    acts_upstream_of_or_within macroautophagy  
    involved_in macroautophagy  
    involved_in macroautophagy  
    involved_in mitophagy  
    involved_in mitophagy  
    involved_in mitotic metaphase chromosome alignment  
    involved_in negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of autophagosome assembly  
    acts_upstream_of_or_within negative regulation of autophagy  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in negative regulation of lysosome organization PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death  
    acts_upstream_of_or_within neuron development  
    involved_in p38MAPK cascade PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process  
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore  
    involved_in positive regulation of autophagosome assembly PubMed 
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    acts_upstream_of_or_within positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of intrinsic apoptotic signaling pathway PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of stress granule assembly PubMed 
    involved_in protein-containing complex assembly  
    involved_in receptor catabolic process  
    involved_in regulation of autophagy  
    acts_upstream_of_or_within regulation of catalytic activity  
    involved_in regulation of cytokinesis  
    involved_in regulation of cytokinesis  
    involved_in regulation of macroautophagy  
    involved_in response to hypoxia PubMed 
    involved_in response to iron(II) ion PubMed 
    involved_in response to lead ion PubMed 
    involved_in response to mitochondrial depolarisation  
    involved_in response to nutrient levels PubMed 
    acts_upstream_of_or_within response to other organism  
    involved_in response to vitamin E PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    Items 1 - 25 of 72
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in autophagosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic side of mitochondrial outer membrane  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endosome  
    located_in endosome membrane  
    located_in mitochondrion  
    located_in nuclear body  
    located_in nuclear body  
    located_in phagocytic vesicle  
    is_active_in phagophore assembly site  
    part_of phosphatidylinositol 3-kinase complex, class III  
    part_of phosphatidylinositol 3-kinase complex, class III  
    part_of phosphatidylinositol 3-kinase complex, class III, type I  
    part_of phosphatidylinositol 3-kinase complex, class III, type II  
    part_of protein-containing complex  
    located_in trans-Golgi network PubMed 
    located_in trans-Golgi network  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    beclin-1
    Names
    beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
    beclin 1, autophagy related
    coiled-coil myosin-like BCL2-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034117.1 → NP_001029289.1  beclin-1

      See identical proteins and their annotated locations for NP_001029289.1

      Status: VALIDATED

      Source sequence(s)
      BC074011, CK600131
      UniProtKB/Swiss-Prot
      Q91XJ1
      UniProtKB/TrEMBL
      A6HJA4
      Conserved Domains (3) summary
      pfam15285
      Location:105 → 127
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
      pfam04111
      Location:265 → 443
      APG6; Autophagy protein Apg6
      pfam17675
      Location:133 → 259
      APG6_N; Apg6 coiled-coil region
    2. NM_053739.2 → NP_446191.1  beclin-1

      See identical proteins and their annotated locations for NP_446191.1

      Status: VALIDATED

      Source sequence(s)
      AY033824, BC074011, CB788828, CK600131
      UniProtKB/Swiss-Prot
      Q91XJ1
      UniProtKB/TrEMBL
      A6HJA4
      Related
      ENSRNOP00000071966.1, ENSRNOT00000082010.3
      Conserved Domains (3) summary
      pfam15285
      Location:105 → 127
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
      pfam04111
      Location:265 → 443
      APG6; Autophagy protein Apg6
      pfam17675
      Location:133 → 259
      APG6_N; Apg6 coiled-coil region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86731649..86747002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085040.1 → XP_038940968.1  beclin-1 isoform X1

      Conserved Domains (1) summary
      pfam04111
      Location:69 → 247
      APG6; Autophagy protein Apg6
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