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    Tpi1 triosephosphate isomerase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24849, updated on 9-Dec-2024

    Summary

    Symbol
    Tpi1provided by RGD
    Full Name
    triosephosphate isomerase 1provided by RGD
    Primary source
    RGD:3896
    See related
    EnsemblRapid:ENSRNOG00000015290 AllianceGenome:RGD:3896
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tpi
    Summary
    Enables triose-phosphate isomerase activity. Predicted to be involved in several processes, including glucose metabolic process; glyceraldehyde-3-phosphate biosynthetic process; and methylglyoxal biosynthetic process. Predicted to act upstream of or within glucose metabolic process. Predicted to be active in cytosol. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 12880.2), Heart (RPKM 3327.9) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Tpi1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159301558..159305088, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157615283..157618813, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157328375..157331905, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102384 Neighboring gene enolase 2 Neighboring gene leucine rich repeat containing 23 Neighboring gene uncharacterized LOC134486638 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene cell division cycle associated 3 Neighboring gene G protein subunit beta 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC156639

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables isomerase activity  
    enables lyase activity  
    enables methylglyoxal synthase activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables triose-phosphate isomerase activity  
    enables triose-phosphate isomerase activity PubMed 
    enables triose-phosphate isomerase activity  
    enables triose-phosphate isomerase activity  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in canonical glycolysis  
    involved_in gluconeogenesis  
    involved_in gluconeogenesis  
    involved_in gluconeogenesis  
    acts_upstream_of_or_within glucose metabolic process  
    involved_in glyceraldehyde-3-phosphate biosynthetic process  
    involved_in glyceraldehyde-3-phosphate biosynthetic process  
    involved_in glyceraldehyde-3-phosphate biosynthetic process  
    involved_in glyceraldehyde-3-phosphate metabolic process  
    involved_in glycerol catabolic process  
    involved_in glycolytic process  
    involved_in glycolytic process  
    involved_in glycolytic process PubMed 
    involved_in methylglyoxal biosynthetic process  
    Component Evidence Code Pubs
    is_active_in cytosol  
    is_active_in cytosol  

    General protein information

    Preferred Names
    triosephosphate isomerase
    Names
    TIM
    methylglyoxal synthase
    triose-phosphate isomerase
    triosephosphate isomerase-like
    NP_075211.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022922.2NP_075211.2  triosephosphate isomerase

      See identical proteins and their annotated locations for NP_075211.2

      Status: PROVISIONAL

      Source sequence(s)
      BC126087
      UniProtKB/Swiss-Prot
      A0JN18, P48500, Q6P793
      UniProtKB/TrEMBL
      A0A8L2R053
      Related
      ENSRNOP00000020647.4, ENSRNOT00000020647.8
      Conserved Domains (1) summary
      PTZ00333
      Location:2247
      PTZ00333; triosephosphate isomerase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159301558..159305088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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