Crisp3 cysteine-rich secretory protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crisp3provided by RGD
Official Full Name: cysteine-rich secretory protein 3provided by RGD
Primary source: RGD:619846
See related: EnsemblRapid:ENSRNOG00000013496 AllianceGenome:RGD:619846
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aeg; Crisp1; Crisp-1
Summary: Predicted to be located in extracellular region and specific granule. Predicted to be active in extracellular space. Orthologous to human CRISP3 (cysteine rich secretory protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 16.2) and Testes (RPKM 14.5) See more
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Genomic context

Location:: 9q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (27928591..27969205)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (20432051..20472663)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (24047405..24088066)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of AEG-1 suppresses autophagy in DCM by downregulating the expression of KLF4. This study provide first-notion evidence for the potential value of AEG-1 as a therapeutic target for the treatment of the patients with DCM.
Title: Astrocyte elevated gene-1 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4.
involvement of CRISP1-Zn(2+) complexes in the association of the loosely bound population of CRISP1 with sperm during epididymal maturation
Title: Evidence for the involvement of zinc in the association of CRISP1 with rat sperm during epididymal maturation.
CRISP1 interacts with sperm transiently, possibly with a specific receptor on the sperm surface, consistent with its action in suppressing capacitation during epididymal storage of sperm
Title: Association of the protein D and protein E forms of rat CRISP1 with epididymal sperm.
Recombinant Crisp1 is able to elicit a specific immune response and inhibit male and female fertility, supporting the use of this sperm epididymal protein for the development of an immunocontraceptive approach.
Title: Immunocontraceptive properties of recombinant sperm protein DE: implications for the development of novel contraceptives.
CRISP1 participates not only in sperm-egg fusion but also in the prior stage of sperm-ZP interaction.
Title: A novel function for CRISP1 in rodent fertilization: involvement in sperm-zona pellucida interaction.
the egg-binding ability of CRISP1 resides within a 45-amino acid N-terminal region containing the two motifs of the CRISP family named Signature 1 and Signature 2, the binding site of CRISP1 resides in an evolutionarily conserved region
Title: Sperm protein "DE" mediates gamete fusion through an evolutionarily conserved site of the CRISP family.
In addition to its influence on protein tyrosine phosphorylation, bicarbonate is required to support other rat sperm capacitation-associated events, such as migration of CRISP-1 to equatorial segment, and expression of ability of sperm to fuse with egg.
Title: Bicarbonate is required for migration of sperm epididymal protein DE (CRISP-1) to the equatorial segment and expression of rat sperm fusion ability.

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General gene information

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Markers

BI281439 (e-PCR)
- UniSTS:249486

D9Wox38 (e-PCR)
- UniSTS:518869

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in specific granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cysteine-rich secretory protein 1

Names: 32 kDa epididymal protein; SCP; acidic epididymal glycoprotein D/E; epididymal glycoprotein; protein D; protein E; protein IV; sialoprotein; sperm-coating glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022859.2 → NP_074050.1 cysteine-rich secretory protein 1 precursor

See identical proteins and their annotated locations for NP_074050.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P12020

UniProtKB/TrEMBL

A0A8I6G5B9

Conserved Domains (2) summary

cd05383
Location:39 → 174

SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

pfam08562
Location:192 → 246

Crisp; Crisp