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    Arhgef11 Rho guanine nucleotide exchange factor 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 78966, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgef11provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 11provided by RGD
    Primary source
    RGD:619705
    See related
    EnsemblRapid:ENSRNOG00000015026 AllianceGenome:RGD:619705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtrap48
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of L-glutamate import across plasma membrane. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 90.3), Kidney (RPKM 85.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgef11 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175372269..175493852)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173074383..173195962)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (186979850..187102523)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102546356 Neighboring gene leucine rich repeat containing 71 Neighboring gene uncharacterized LOC134485635 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene neurotrophic receptor tyrosine kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding  
    enables G protein-coupled receptor binding  
    enables G protein-coupled receptor binding  
    enables GTPase activator activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity PubMed 
    enables guanyl-nucleotide exchange factor activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 11
    Names
    Rho guanine nucleotide exchange factor (GEF) 11
    RhoGEF glutamate transport modulator GTRAP48
    glutamate transporter EAAT4 associated protein 48

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023982.3NP_076472.2  rho guanine nucleotide exchange factor 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9ES67
      Related
      ENSRNOP00000083614.2, ENSRNOT00000119098.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175372269..175493852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232759.3XP_006232821.1  rho guanine nucleotide exchange factor 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Conserved Domains (6) summary
      PRK12782
      Location:269358
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:347491
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:78154
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:63128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9971139
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:796980
      RhoGEF; RhoGEF domain
    2. XM_039103185.2XP_038959113.1  rho guanine nucleotide exchange factor 11 isoform X16

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Conserved Domains (6) summary
      PRK12782
      Location:269358
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:347491
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:796980
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:12911420
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:63128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9971139
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    3. XM_039103180.2XP_038959108.1  rho guanine nucleotide exchange factor 11 isoform X7

      UniProtKB/Swiss-Prot
      Q9ES67
      Conserved Domains (6) summary
      PRK12782
      Location:269358
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:347491
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:786970
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11241452
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:63128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9871129
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    4. XM_039103176.2XP_038959104.1  rho guanine nucleotide exchange factor 11 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Conserved Domains (6) summary
      PRK12782
      Location:269358
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:347491
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:795979
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11421461
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:63128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9961138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    5. XM_039103181.2XP_038959109.1  rho guanine nucleotide exchange factor 11 isoform X8

      UniProtKB/Swiss-Prot
      Q9ES67
      Related
      ENSRNOP00000086176.2, ENSRNOT00000114540.2
      Conserved Domains (6) summary
      PRK12782
      Location:269358
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:347491
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:785969
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11231451
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:63128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9861128
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    6. XM_039103188.2XP_038959116.1  rho guanine nucleotide exchange factor 11 isoform X20

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Conserved Domains (5) summary
      cd08753
      Location:301445
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:750934
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:10881416
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:63128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9511093
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    7. XM_039103184.2XP_038959112.1  rho guanine nucleotide exchange factor 11 isoform X17

      UniProtKB/Swiss-Prot
      Q9ES67
      Conserved Domains (6) summary
      PRK12782
      Location:229318
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:307451
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:756940
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:10941422
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:63128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9571099
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    8. XM_039103189.2XP_038959117.1  rho guanine nucleotide exchange factor 11 isoform X25

      UniProtKB/Swiss-Prot
      Q9ES67
      Conserved Domains (5) summary
      cd08753
      Location:261405
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:710894
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:10481376
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:63128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9111053
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    9. XM_039103177.2XP_038959105.1  rho guanine nucleotide exchange factor 11 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Conserved Domains (6) summary
      PRK12782
      Location:268357
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:795979
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11331461
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:62127
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9961138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    10. XM_039103178.2XP_038959106.1  rho guanine nucleotide exchange factor 11 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Conserved Domains (6) summary
      PRK12782
      Location:268357
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:794978
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11321460
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:62127
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9951137
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    11. XM_039103182.2XP_038959110.1  rho guanine nucleotide exchange factor 11 isoform X9

      UniProtKB/Swiss-Prot
      Q9ES67
      Conserved Domains (6) summary
      PRK12782
      Location:268357
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:784968
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11221450
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:62127
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9851127
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    12. XM_039103186.2XP_038959114.1  rho guanine nucleotide exchange factor 11 isoform X18

      UniProtKB/Swiss-Prot
      Q9ES67
      Conserved Domains (6) summary
      PRK12782
      Location:228317
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:306450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:755939
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:10931421
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:62127
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9561098
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    13. XM_039103187.2XP_038959115.1  rho guanine nucleotide exchange factor 11 isoform X19

      UniProtKB/Swiss-Prot
      Q9ES67
      Conserved Domains (6) summary
      PRK12782
      Location:228317
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:306450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:754938
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11011420
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:62127
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9551097
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    14. XM_017591126.3XP_017446615.1  rho guanine nucleotide exchange factor 11 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AAM2
    15. XM_063282598.1XP_063138668.1  rho guanine nucleotide exchange factor 11 isoform X10

      UniProtKB/Swiss-Prot
      Q9ES67
      Related
      ENSRNOP00000086384.2, ENSRNOT00000106820.2
    16. XM_039103179.2XP_038959107.1  rho guanine nucleotide exchange factor 11 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Conserved Domains (6) summary
      PRK12782
      Location:263352
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:341485
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:790974
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11281456
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:57122
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9911133
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    17. XM_006232766.3XP_006232828.1  rho guanine nucleotide exchange factor 11 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A5B5, A0A8I6AAM2
      Related
      ENSRNOP00000088812.2, ENSRNOT00000116714.2
      Conserved Domains (6) summary
      PRK12782
      Location:253342
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:331475
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:62138
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:47112
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9811123
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:780964
      RhoGEF; RhoGEF domain
    18. XM_063282600.1XP_063138670.1  rho guanine nucleotide exchange factor 11 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A8L7, A0A8I6AAM2
    19. XM_063282599.1XP_063138669.1  rho guanine nucleotide exchange factor 11 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Related
      ENSRNOP00000020717.8, ENSRNOT00000020717.9
    20. XM_063282601.1XP_063138671.1  rho guanine nucleotide exchange factor 11 isoform X15

      UniProtKB/TrEMBL
      A0A8I6AAM2
    21. XM_063282602.1XP_063138672.1  rho guanine nucleotide exchange factor 11 isoform X21

      UniProtKB/Swiss-Prot
      Q9ES67
      Related
      ENSRNOP00000108218.1, ENSRNOT00000157908.1
    22. XM_063282604.1XP_063138674.1  rho guanine nucleotide exchange factor 11 isoform X23

      UniProtKB/Swiss-Prot
      Q9ES67
      Related
      ENSRNOP00000070996.3, ENSRNOT00000091336.3
    23. XM_063282603.1XP_063138673.1  rho guanine nucleotide exchange factor 11 isoform X22

      UniProtKB/Swiss-Prot
      Q9ES67
    24. XM_063282605.1XP_063138675.1  rho guanine nucleotide exchange factor 11 isoform X24

      UniProtKB/Swiss-Prot
      Q9ES67
    25. XM_039103183.2XP_038959111.1  rho guanine nucleotide exchange factor 11 isoform X13

      UniProtKB/TrEMBL
      A0A8I6AAM2
      Conserved Domains (6) summary
      PRK12782
      Location:252341
      flgC; flagellar basal body rod protein FlgC; Reviewed
      cd08753
      Location:330474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:779963
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK07764
      Location:11171445
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00992
      Location:46111
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9801122
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    26. XM_063282606.1XP_063138676.1  rho guanine nucleotide exchange factor 11 isoform X26

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