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    Cplx1 complexin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64832, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cplx1provided by RGD
    Official Full Name
    complexin 1provided by RGD
    Primary source
    RGD:70944
    See related
    EnsemblRapid:ENSRNOG00000090522 AllianceGenome:RGD:70944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Orthologous to human CPLX1 (complexin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 725.8) See more
    Orthologs
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    Genomic context

    See Cplx1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (1329073..1360781)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1184677..1216392)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (2194895..2226610)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 175 Neighboring gene cyclin G associated kinase Neighboring gene U6 spliceosomal RNA Neighboring gene polycomb group ring finger 3 Neighboring gene solute carrier family 49 member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding  
    enables SNARE binding PubMed 
    enables lipid binding  
    enables syntaxin-1 binding PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex  
    part_of SNARE complex  
    is_active_in Schaffer collateral - CA1 synapse  
    is_active_in calyx of Held  
    located_in cytosol  
    located_in dendrite PubMed 
    is_active_in glutamatergic synapse  
    located_in neuronal cell body PubMed 
    located_in perikaryon  
    is_active_in postsynapse PubMed 
    is_active_in postsynapse  
    is_active_in presynapse PubMed 
    is_active_in presynapse  
    part_of protein-containing complex PubMed 
    located_in synapse PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex PubMed 
    located_in terminal bouton PubMed 
    is_active_in terminal bouton  

    General protein information

    Preferred Names
    complexin-1
    Names
    CPX I
    complexin I
    synaphin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022864.4NP_074055.1  complexin-1

      See identical proteins and their annotated locations for NP_074055.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P63041, Q566D7
      UniProtKB/TrEMBL
      A6KPF0
      Related
      ENSRNOP00000107898.1, ENSRNOT00000123905.1
      Conserved Domains (1) summary
      pfam05835
      Location:1133
      Synaphin; Synaphin protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      1329073..1360781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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