Chp1 calcineurin-like EF-hand protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chp1provided by RGD
Official Full Name: calcineurin-like EF-hand protein 1provided by RGD
Primary source: RGD:620447
See related: EnsemblRapid:ENSRNOG00000004742 AllianceGenome:RGD:620447
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Chp; Wrch2
Summary: Enables calcium ion binding activity; kinase binding activity; and microtubule binding activity. Involved in several processes, including microtubule cytoskeleton organization; protein export from nucleus; and regulation of protein modification process. Located in several cellular components, including Golgi membrane; endoplasmic reticulum; and transport vesicle. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to human CHP1 (calcineurin like EF-hand protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 372.0), Liver (RPKM 318.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (126989800..127025071)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (106536009..106571255)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (111354506..111389998)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHP1 contains a hydrophobic pocket on the opposite side of the protein to the EF-hands that has been implicated in ligand binding
Title: Structural characterization of calcineurin B homologous protein 1.
The p22 modulates the organization and dynamics of microtubule cytoskeleton in a Ca(2+)-independent manner and affects ER network assembly in a Ca(2+)-dependent manner.
Title: The EF-hand Ca2+-binding protein p22 plays a role in microtubule and endoplasmic reticulum organization and dynamics with distinct Ca2+-binding requirements.
Results suggest that after CHP1 has entered the nucleus, it is exported to the cytoplasm in a nuclear export signal-dependent manner.
Title: Two nuclear export signals specify the cytoplasmic localization of calcineurin B homologous protein 1.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134406 (e-PCR)
- UniSTS:217688

RH143965 (e-PCR)
- UniSTS:233211

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic microtubule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane docking	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule bundle formation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein complex oligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle targeting	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of transporter complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcineurin B homologous protein 1

Names: EF-hand Ca2+-binding protein p22; EF-hand calcium-binding domain-containing protein p22; calcineurin B-like protein; calcineurin homologous protein; calcium-binding protein CHP; calcium-binding protein p22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024139.2 → NP_077053.1 calcineurin B homologous protein 1

See identical proteins and their annotated locations for NP_077053.1

Status: PROVISIONAL

Source sequence(s)

BC062029

UniProtKB/Swiss-Prot

P61023

UniProtKB/TrEMBL

A6HPF8, A6HPG0

Related

ENSRNOP00000053243.2, ENSRNOT00000056405.4

Conserved Domains (1) summary

COG5126
Location:1 → 182

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]