Clic5 chloride intracellular channel 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clic5provided by RGD
Official Full Name: chloride intracellular channel 5provided by RGD
Primary source: RGD:620659
See related: EnsemblRapid:ENSRNOG00000074354 AllianceGenome:RGD:620659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chloride channel activity. Predicted to be involved in chloride transport; inner ear receptor cell stereocilium organization; and sensory perception of sound. Predicted to act upstream of or within several processes, including auditory receptor cell stereocilium organization; diet induced thermogenesis; and neuromuscular process controlling balance. Located in apical plasma membrane; mitochondrial inner membrane; and stereocilium base. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Orthologous to human CLIC5 (chloride intracellular channel 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 492.0), Spleen (RPKM 319.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (24208455..24310964, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (16710980..16813502, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (19121676..19372673, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors report the presence of unique dimorphic chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4, CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to adult cardiac mitochondria.
Title: Molecular identity of cardiac mitochondrial chloride intracellular channel proteins.
Study identifies CLIC5 as a new component that is enriched in and necessary for foot process integrity and podocyte function in vivo.
Title: Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU046523 (e-PCR)
- UniSTS:111369

AU028825 (e-PCR)
- UniSTS:111950

AU028820 (e-PCR)
- UniSTS:111955

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium base	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium base	ISO Inferred from Sequence Orthology more info
located_in stereocilium bundle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chloride intracellular channel protein 5

Names: glutaredoxin-like oxidoreductase CLIC5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.