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    Pcsk7 proprotein convertase subtilisin/kexin type 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcsk7provided by RGD
    Official Full Name
    proprotein convertase subtilisin/kexin type 7provided by RGD
    Primary source
    RGD:3275
    See related
    EnsemblRapid:ENSRNOG00000017478 AllianceGenome:RGD:3275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PC7
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in Golgi membrane and trans-Golgi network. Orthologous to human PCSK7 (proprotein convertase subtilisin/kexin type 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 95.3), Kidney (RPKM 94.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcsk7 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55098821..55121416)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46202079..46224699)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50200069..50222655)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene beta-secretase 1 Neighboring gene ring finger protein 214 Neighboring gene transgelin Neighboring gene uncharacterized LOC120094332 Neighboring gene SID1 transmembrane family, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The proprotein convertase PC7: unique zymogen activation and trafficking pathways. Rousselet E, et al. J Biol Chem, 2011 Jan 28. PMID 21075846, Free PMC Article
    2. Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase. van de Loo JW, et al. J Biol Chem, 1997 Oct 24. PMID 9341152
    3. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Seidah NG, et al. Proc Natl Acad Sci U S A, 1996 Apr 16. PMID 8622945, Free PMC Article
    4. Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport. Kato S, et al. Am J Physiol Lung Cell Mol Physiol, 2013 Jul 15. PMID 23686857, Free PMC Article
    5. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. Wickham L, et al. J Neurochem, 2005 Jan. PMID 15606899

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
      Title: Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
    2. PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.
      Title: The proprotein convertase PC7: unique zymogen activation and trafficking pathways.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 7
    Names
    prohormone convertase 7
    prohormone convertase PC7
    proprotein convertase 7
    proprotein convertase PC7
    rPC7
    subtilisin/kexin-like protease PC7
    NP_062119.1
    XP_038936896.1
    XP_063121098.1
    XP_063121099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019246.2 → NP_062119.1  proprotein convertase subtilisin/kexin type 7 precursor

      See identical proteins and their annotated locations for NP_062119.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q62849
      UniProtKB/TrEMBL
      A6J459
      Related
      ENSRNOP00000023677.3, ENSRNOT00000023677.6
      Conserved Domains (4) summary
      cd04059
      Location:144 → 439
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:195 → 439
      Peptidase_S8; Subtilase family
      pfam01483
      Location:524 → 611
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:52 → 140
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55098821..55121416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265028.1 → XP_063121098.1  proprotein convertase subtilisin/kexin type 7 isoform X1

      UniProtKB/Swiss-Prot
      Q62849
      UniProtKB/TrEMBL
      A6J459

    2. XM_039080968.2 → XP_038936896.1  proprotein convertase subtilisin/kexin type 7 isoform X2

      Conserved Domains (2) summary
      cd04059
      Location:2 → 224
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:309 → 396
      P_proprotein; Proprotein convertase P-domain

    3. XM_063265029.1 → XP_063121099.1  proprotein convertase subtilisin/kexin type 7 isoform X3

    RNA

    1. XR_005487748.2 RNA Sequence

    2. XR_005487749.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62849.1 GenPept UniProtKB/Swiss-Prot:Q62849

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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