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    Dhcr7 7-dehydrocholesterol reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64191, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dhcr7provided by RGD
    Official Full Name
    7-dehydrocholesterol reductaseprovided by RGD
    Primary source
    RGD:621769
    See related
    EnsemblRapid:ENSRNOG00000020776 AllianceGenome:RGD:621769
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 7-dehydrocholesterol reductase activity. Involved in cholesterol biosynthetic process and regulation of cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum and nuclear outer membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Behcet's disease and Smith-Lemli-Opitz syndrome. Orthologous to human DHCR7 (7-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 460.5), Liver (RPKM 232.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Dhcr7 in Genome Data Viewer
    Location:
    1q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208444434..208460408)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (199015081..199031055)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (217018916..217034890)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member E Neighboring gene NAD synthetase 1 Neighboring gene actin-like Neighboring gene 60S ribosomal protein L21-like Neighboring gene SH3 and multiple ankyrin repeat domains 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93039

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 7-dehydrocholesterol reductase activity  
    enables 7-dehydrocholesterol reductase activity  
    enables 7-dehydrocholesterol reductase activity PubMed 
    enables 7-dehydrocholesterol reductase activity  
    enables 7-dehydrocholesterol reductase activity PubMed 
    enables NADP binding  
    enables cholesterol-5,6-oxide hydrolase activity  
    enables cholesterol-5,6-oxide hydrolase activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development  
    involved_in cholesterol biosynthetic process  
    involved_in cholesterol biosynthetic process PubMed 
    involved_in cholesterol biosynthetic process PubMed 
    involved_in cholesterol biosynthetic process PubMed 
    involved_in cholesterol biosynthetic process  
    involved_in cholesterol biosynthetic process PubMed 
    involved_in cholesterol biosynthetic process via lathosterol  
    involved_in cholesterol biosynthetic process via lathosterol  
    acts_upstream_of_or_within lung development  
    acts_upstream_of_or_within lung epithelial cell differentiation  
    acts_upstream_of_or_within multicellular organism growth  
    involved_in positive regulation of ferroptosis  
    involved_in positive regulation of ferroptosis  
    acts_upstream_of_or_within post-embryonic development  
    acts_upstream_of_or_within regulation of cell population proliferation  
    involved_in regulation of cholesterol biosynthetic process PubMed 
    acts_upstream_of_or_within sterol biosynthetic process  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in nuclear outer membrane  
    located_in nuclear outer membrane  

    General protein information

    Preferred Names
    7-dehydrocholesterol reductase
    Names
    7-DHC reductase
    sterol Delta(7)-reductase
    NP_071784.1
    XP_006230955.1
    XP_006230956.1
    XP_038945428.1
    XP_063128807.1
    XP_063128808.1
    XP_063128809.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022389.3NP_071784.1  7-dehydrocholesterol reductase

      See identical proteins and their annotated locations for NP_071784.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q9Z2Z8
      UniProtKB/TrEMBL
      A0A8L2R4U0, A6HYE0
      Related
      ENSRNOP00000028194.3, ENSRNOT00000028195.7
      Conserved Domains (1) summary
      cl21511
      Location:89471
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      208444434..208460408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272737.1XP_063128807.1  7-dehydrocholesterol reductase isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2Z8
      UniProtKB/TrEMBL
      A0A8L2R4U0, A6HYE0
    2. XM_006230893.5XP_006230955.1  7-dehydrocholesterol reductase isoform X1

      See identical proteins and their annotated locations for XP_006230955.1

      UniProtKB/Swiss-Prot
      Q9Z2Z8
      UniProtKB/TrEMBL
      A0A8L2R4U0, A6HYE0
      Related
      ENSRNOP00000071939.2, ENSRNOT00000078979.3
      Conserved Domains (1) summary
      cl21511
      Location:89471
      PEMT; Phospholipid methyltransferase
    3. XM_039089500.2XP_038945428.1  7-dehydrocholesterol reductase isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2Z8
      UniProtKB/TrEMBL
      A0A8L2R4U0, A6HYE0
      Conserved Domains (1) summary
      cl21511
      Location:89471
      PEMT; Phospholipid methyltransferase
    4. XM_006230894.5XP_006230956.1  7-dehydrocholesterol reductase isoform X1

      See identical proteins and their annotated locations for XP_006230956.1

      UniProtKB/Swiss-Prot
      Q9Z2Z8
      UniProtKB/TrEMBL
      A0A8L2R4U0, A6HYE0
      Conserved Domains (1) summary
      cl21511
      Location:89471
      PEMT; Phospholipid methyltransferase
    5. XM_063272739.1XP_063128809.1  7-dehydrocholesterol reductase isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2Z8
      UniProtKB/TrEMBL
      A0A8L2R4U0, A6HYE0
    6. XM_063272738.1XP_063128808.1  7-dehydrocholesterol reductase isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2Z8
      UniProtKB/TrEMBL
      A0A8L2R4U0, A6HYE0
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