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    Hipk3 homeodomain interacting protein kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83617, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hipk3provided by RGD
    Official Full Name
    homeodomain interacting protein kinase 3provided by RGD
    Primary source
    RGD:619884
    See related
    EnsemblRapid:ENSRNOG00000011358 AllianceGenome:RGD:619884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ANPK
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in several processes, including mRNA transcription; negative regulation of JUN kinase activity; and protein phosphorylation. Predicted to be located in cytosol; nuclear body; and plasma membrane. Predicted to be active in PML body and cytoplasm. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 646.6), Muscle (RPKM 605.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hipk3 in Genome Data Viewer
    Location:
    3q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (111251863..111322815, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (90796980..90866701, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (94349778..94419185, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D430041D05 gene like Neighboring gene similar to human chromosome 11 open reading frame 91 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene cleavage stimulation factor subunit 3 Neighboring gene t-complex 11 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein tyrosine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in chromatin remodeling  
    involved_in mRNA transcription  
    involved_in mRNA transcription  
    involved_in negative regulation of JUN kinase activity  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-threonine phosphorylation  
    involved_in protein phosphorylation  
    Component Evidence Code Pubs
    is_active_in PML body  
    located_in PML body  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear body  
    located_in nuclear body  
    is_active_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 3
    Names
    androgen receptor-interacting nuclear protein kinase
    nuclear serine/threonine protein kinase
    NP_001382009.1
    NP_113975.2
    XP_008760294.2
    XP_063140716.1
    XP_063140717.1
    XP_063140718.1
    XP_063140719.1
    XP_063140720.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395080.1NP_001382009.1  homeodomain-interacting protein kinase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88850
      UniProtKB/TrEMBL
      Q498U5
      Related
      ENSRNOP00000015775.3, ENSRNOT00000015775.5
      Conserved Domains (1) summary
      cd14229
      Location:196525
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3
    2. NM_031787.2NP_113975.2  homeodomain-interacting protein kinase 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88850
      UniProtKB/TrEMBL
      A6HNU0, F7EY07
      Conserved Domains (1) summary
      cd14229
      Location:196525
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      111251863..111322815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762072.4XP_008760294.2  homeodomain-interacting protein kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K4W6
    2. XM_063284647.1XP_063140717.1  homeodomain-interacting protein kinase 3 isoform X2

      UniProtKB/Swiss-Prot
      O88850
    3. XM_063284646.1XP_063140716.1  homeodomain-interacting protein kinase 3 isoform X1

      UniProtKB/Swiss-Prot
      O88850
      UniProtKB/TrEMBL
      A0A8I6GE65
      Related
      ENSRNOP00000085704.1, ENSRNOT00000105868.2
    4. XM_063284650.1XP_063140720.1  homeodomain-interacting protein kinase 3 isoform X5

    5. XM_063284649.1XP_063140719.1  homeodomain-interacting protein kinase 3 isoform X4

    6. XM_063284648.1XP_063140718.1  homeodomain-interacting protein kinase 3 isoform X3

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