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    Wipi1 WD repeat domain, phosphoinositide interacting 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303630, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wipi1provided by RGD
    Official Full Name
    WD repeat domain, phosphoinositide interacting 1provided by RGD
    Primary source
    RGD:1307754
    See related
    EnsemblRapid:ENSRNOG00000003827 AllianceGenome:RGD:1307754
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307754
    Summary
    Predicted to enable several functions, including nuclear receptor binding activity; phosphatidylinositol phosphate binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of autophagosome assembly; and vesicle targeting, trans-Golgi to endosome. Predicted to be located in bounding membrane of organelle; phagophore assembly site; and trans-Golgi network. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WIPI1 (WD repeat domain, phosphoinositide interacting 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 179.4), Muscle (RPKM 86.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Wipi1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95042451..95079679, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94542946..94580174, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97859730..97896949, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene arylsulfatase G Neighboring gene solute carrier family 16, member 6 Neighboring gene 5E5 antigen-like Neighboring gene uncharacterized LOC100912202 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase Neighboring gene uncharacterized LOC134480894

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in autophagosome assembly  
    involved_in autophagy  
    involved_in autophagy of mitochondrion  
    involved_in autophagy of peroxisome  
    involved_in biological_process  
    involved_in cellular response to starvation  
    involved_in glycophagy  
    involved_in nucleophagy  
    involved_in positive regulation of autophagosome assembly  
    involved_in protein lipidation involved in autophagosome assembly  
    involved_in protein localization to phagophore assembly site  
    involved_in vesicle targeting, trans-Golgi to endosome  
    Component Evidence Code Pubs
    located_in autophagosome membrane  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in endosome membrane  
    located_in phagophore assembly site  
    is_active_in phagophore assembly site membrane  
    located_in phagophore assembly site membrane  
    located_in trans-Golgi network  

    General protein information

    Preferred Names
    WD repeat domain phosphoinositide-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127297.1NP_001120769.1  WD repeat domain phosphoinositide-interacting protein 1

      See identical proteins and their annotated locations for NP_001120769.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166829
      UniProtKB/TrEMBL
      A0A8I5ZTL1, B2RYM2, F1LPN5
      Related
      ENSRNOP00000101117.1, ENSRNOT00000153625.1
      Conserved Domains (2) summary
      sd00039
      Location:144184
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:120352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      95042451..95079679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768367.3XP_008766589.1  WD repeat domain phosphoinositide-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YNM5
      Conserved Domains (3) summary
      COG2319
      Location:38262
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64102
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:18180
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_039086173.2XP_038942101.1  WD repeat domain phosphoinositide-interacting protein 1 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:3169
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:31147
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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