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    Orc5 origin recognition complex, subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orc5provided by RGD
    Official Full Name
    origin recognition complex, subunit 5provided by RGD
    Primary source
    RGD:1561088
    See related
    EnsemblRapid:ENSRNOG00000011519 AllianceGenome:RGD:1561088
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Orc5l
    Summary
    Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and regulation of DNA replication. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 99.3), Testes (RPKM 85.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Orc5 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (13440264..13504888)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (12548007..12612611)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (9160050..9223998)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC120102148 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973
    2. A WD-repeat protein stabilizes ORC binding to chromatin. Shen Z, et al. Mol Cell, 2010 Oct 8. PMID 20932478, Free PMC Article
    3. The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. Coulombe P, et al. Nat Commun, 2019 Jun 3. PMID 31160578, Free PMC Article
    4. Purification of proteins associated with specific genomic Loci. Déjardin J, et al. Cell, 2009 Jan 9. PMID 19135898, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014186.1 → NP_001014208.1  origin recognition complex subunit 5

      See identical proteins and their annotated locations for NP_001014208.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088447
      UniProtKB/TrEMBL
      A0A8I5ZZ61, A6K597, F7F3U3, Q5M7U2
      Related
      ENSRNOP00000015426.4, ENSRNOT00000015426.7
      Conserved Domains (3) summary
      COG1474
      Location:11 → 191
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13191
      Location:8 → 155
      AAA_16; AAA ATPase domain
      pfam14630
      Location:177 → 431
      ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      13440264..13504888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235947.5 → XP_006236009.1  origin recognition complex subunit 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6D6
      Related
      ENSRNOP00000073770.1, ENSRNOT00000090600.3
      Conserved Domains (3) summary
      COG1474
      Location:11 → 191
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13191
      Location:8 → 155
      AAA_16; AAA ATPase domain
      pfam14630
      Location:177 → 492
      ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

    2. XM_039107753.2 → XP_038963681.1  origin recognition complex subunit 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZ61
      Related
      ENSRNOP00000084482.2, ENSRNOT00000115552.2
    Nucleotide Protein Strain
    Heading Accession and Version

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