Snapin SNAP-associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Snapinprovided by RGD
Official Full Name: SNAP-associated proteinprovided by RGD
Primary source: RGD:1560377
See related: AllianceGenome:RGD:1560377
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Snapap
Summary: Predicted to enable SNARE binding activity. Predicted to be involved in several processes, including anterograde synaptic vesicle transport; endosome to lysosome transport; and synaptic vesicle exocytosis. Predicted to act upstream of or within several processes, including lysosomal lumen acidification; terminal button organization; and vesicle organization. Located in secretory granule. Is active in glutamatergic synapse and synaptic vesicle. Orthologous to human SNAPIN (SNAP associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 294.3), Heart (RPKM 275.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (178269157..178271746, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (175971575..175974164, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189878159..189880743, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In pancreatic beta-cells the SNAP-25 accessory protein, snapin, C-terminal H2 domain binds SNAP-25 through its N-terminal Sn-1 domain.
Title: Snapin mediates insulin secretory granule docking, but not trans-SNARE complex formation.
AC6-mediated inhibition of neurite outgrowth was reversed by the overexpression of Snap25 or a Snapin mutant that could not be phosphorylated.
Title: Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.
EHD1 is a synaptic protein that negatively affects exocytosis through binding to snapin
Title: EHD1 is a synaptic protein that modulates exocytosis through binding to snapin.
activates alpha 1 Adrenergic Receptor and induces calcium influx through TRPC6 channels.
Title: [Roles of Snapin in alpha(1A)-adrenoceptor-induced calcium influx through TRPC6 channels].
torsinA plays a role together with snapin in regulated exocytosis
Title: The dystonia-associated protein torsinA modulates synaptic vesicle recycling.
UT-A1 may be linked to the SNARE machinery via snapin and this interaction may be functionally and physiologically important for urea transport
Title: The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.
Snapin links the alpha(1A)-AR to TRPC6, augmenting Ca(2+) influx via ROC channels
Title: Snapin, a new regulator of receptor signaling, augments alpha1A-adrenoceptor-operated calcium influx through TRPC6.
Snapin binds to a 170-residue predicted ryanodine receptor cytosolic loop (RyR2 residues 4596-4765), containing a hydrophobic segment required for snapin interaction.
Title: Ryanodine receptor interaction with the SNARE-associated protein snapin.
our data suggest that snapin regulates dendrite number in developing neurons by modulating cypin-promoted microtubule assembly.
Title: A novel role for snapin in dendrite patterning: interaction with cypin.
EBAG9 and Snapin have roles in controlling exocytosis processes
Title: EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA799709 (e-PCR)
- UniSTS:260622

RH134098 (e-PCR)
- UniSTS:217380

RH141438 (e-PCR)
- UniSTS:223432

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IEA Inferred from Electronic Annotation more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde synaptic vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within autophagosome maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of vesicle localization	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within late endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosomal lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysosome localization	IEA Inferred from Electronic Annotation more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retrograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic vesicle fusion to presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic vesicle maturation	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within terminal button organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BLOC-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BLOC-1 complex	IEA Inferred from Electronic Annotation more info
part_of BLOC-1 complex	ISO Inferred from Sequence Orthology more info
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of BORC complex	IEA Inferred from Electronic Annotation more info
part_of BORC complex	ISO Inferred from Sequence Orthology more info
part_of BORC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in manchette	ISO Inferred from Sequence Orthology more info
is_active_in microvesicle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SNARE-associated protein Snapin

Names: BLOC-1 subunit 7; SNARE associated protein snapin; biogenesis of lysosome-related organelles complex 1 subunit 7; synaptosomal-associated protein 25-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025648.2 → NP_001020819.1 SNARE-associated protein Snapin isoform 2

See identical proteins and their annotated locations for NP_001020819.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an additional segment in the 5' region and initiates translation at a downstream start codon compared to variant 1. These differences produce a unique 5' UTR and a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

FN803363, JAXUCZ010000002

UniProtKB/TrEMBL

Q4KM25

Conserved Domains (1) summary

pfam14712
Location:9 → 56

Snapin_Pallidin; Snapin/Pallidin
NM_001170576.2 → NP_001164047.1 SNARE-associated protein Snapin isoform 1

See identical proteins and their annotated locations for NP_001164047.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC098864, DY315040

UniProtKB/Swiss-Prot

P60192

UniProtKB/TrEMBL

A6J6M5

Conserved Domains (1) summary

pfam14712
Location:24 → 110

Snapin_Pallidin; Snapin/Pallidin