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    Vipr2 vasoactive intestinal peptide receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vipr2provided by RGD
    Official Full Name
    vasoactive intestinal peptide receptor 2provided by RGD
    Primary source
    RGD:3962
    See related
    EnsemblRapid:ENSRNOG00000004317 AllianceGenome:RGD:3962
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables vasoactive intestinal polypeptide receptor activity. Involved in activation of adenylate cyclase activity and negative regulation of smooth muscle cell proliferation. Predicted to be active in plasma membrane. Orthologous to human VIPR2 (vasoactive intestinal peptide receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 29.3), Thymus (RPKM 27.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vipr2 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143139672..143213609)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (136996664..137070599)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (143932960..144009476)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene Ig heavy chain V region 3-like Neighboring gene zinc finger protein 386 (Kruppel-like) Neighboring gene chromatin target of PRMT1, pseudogene 1 Neighboring gene uncharacterized LOC134479489

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions. Usdin TB, et al. Endocrinology, 1994 Dec. PMID 7988457
    2. The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide. Lutz EM, et al. FEBS Lett, 1993 Nov 8. PMID 8224221
    3. VPAC2-R mediates the lipolytic effects of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide in primary rat adipocytes. Akesson L, et al. Endocrinology, 2005 Feb. PMID 15514088
    4. Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia. Garry EM, et al. Mol Cell Neurosci, 2005 Dec. PMID 16202621
    5. VPAC2 receptor activation mediates VIP enhancement of population spikes in the CA1 area of the hippocampus. Cunha-Reis D, et al. Ann N Y Acad Sci, 2006 Jul. PMID 16888168

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic beta cells.
      Title: VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic β cells.
    2. PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
      Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
    3. the protein and mRNA expression of pituitary adenylate cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to identify changes associated with repetitive applications of chemical dural stimulations.
      Title: Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats.
    4. In cultured rat conjunctival goblet cells, VPAC1 and 2 receptors are functional; VIP stimulates a cAMP-dependent increase in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2 activation.
      Title: Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.
    5. Although cerebellar arteries expressed transcripts for all three PACAP receptor subtypes, middle meningeal arteries demonstrated only PAC1 and VPAC2 receptor expression.
      Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) potently dilates middle meningeal arteries: implications for migraine.
    6. both VPAC1 and VPAC2 could have roles at all stages of retinal development, that PACAP acts through a specific set of PAC1 isoforms, and that Hip and Hop1 are predominantly involved in the postnatal development of rat retina.
      Title: Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina.
    7. Expression and distribution of vasoactive intestinal peptide receptor 2 remains unchanged in aged rat brains.
      Title: Region-specific changes in the immunoreactivity of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC2, and PAC1 receptor) in the aged rat brains.
    8. investigation of role of VPAC2 (& VPAC1) in pulmonary circulation in health/disease: distribution of VPAC2 (& VPAC1) in aorta/pulmonary artery (& smooth muscle cells); effects of VPAC antagonists on cell proliferation; dominant role of VPAC2
      Title: Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation.
    9. Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats.
      Title: Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats.
    10. inhibitory effect of pituitary adenylate cyclase-activating polypeptide on food intake may be mediated, at least in part, through modulation of neuropeptide Y neurotransmission
      Title: Expression of PACAP receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pituitary adenylate cyclase-activating polypeptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pituitary adenylate cyclase-activating polypeptide receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables vasoactive intestinal polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables vasoactive intestinal polypeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables vasoactive intestinal polypeptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vasoactive intestinal polypeptide receptor 2
    Names
    PACAP type III receptor
    PACAP-R-3
    PACAP-R3
    VIP-R-2
    pituitary adenylate cyclase-activating polypeptide type III receptor
    vasopressive intestinal peptide receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017238.2 → NP_058934.2  vasoactive intestinal polypeptide receptor 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P35000
      UniProtKB/TrEMBL
      A6KDK7
      Related
      ENSRNOP00000005876.5, ENSRNOT00000005876.6
      Conserved Domains (2) summary
      smart00008
      Location:47 → 117
      HormR; Domain present in hormone receptors
      cd15986
      Location:122 → 390
      7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      143139672..143213609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594055.3 → XP_017449544.1  vasoactive intestinal polypeptide receptor 2 isoform X1

    2. XM_063261586.1 → XP_063117656.1  vasoactive intestinal polypeptide receptor 2 isoform X1

    3. XM_039111853.2 → XP_038967781.1  vasoactive intestinal polypeptide receptor 2 isoform X5

      Conserved Domains (1) summary
      smart00008
      Location:47 → 117
      HormR; Domain present in hormone receptors

    4. XM_039111850.2 → XP_038967778.1  vasoactive intestinal polypeptide receptor 2 isoform X2

      Conserved Domains (3) summary
      smart00008
      Location:47 → 117
      HormR; Domain present in hormone receptors
      cd14964
      Location:276 → 303
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:247 → 345
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_039111852.2 → XP_038967780.1  vasoactive intestinal polypeptide receptor 2 isoform X4

      Conserved Domains (1) summary
      smart00008
      Location:47 → 117
      HormR; Domain present in hormone receptors

    6. XM_039111851.2 → XP_038967779.1  vasoactive intestinal polypeptide receptor 2 isoform X3

      Conserved Domains (2) summary
      cd14964
      Location:20 → 42
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:13 → 252
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_005505447.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35000.1 GenPept UniProtKB/Swiss-Prot:P35000

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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