U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fzd6 frizzled class receptor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282581, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Fzd6provided by RGD
    Official Full Name
    frizzled class receptor 6provided by RGD
    Primary source
    RGD:628816
    See related
    EnsemblRapid:ENSRNOG00000004660 AllianceGenome:RGD:628816
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Wnt receptor activity; Wnt-protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Predicted to be located in apical plasma membrane; apicolateral plasma membrane; and endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 79.3), Kidney (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Fzd6 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (71939916..71971685)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (70055012..70086781)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (77898329..77931034)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene BAALC binder of MAP3K1 and KLF4 Neighboring gene uncharacterized LOC134479898 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479899

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Frizzled6 controls hair patterning in mice. Guo N, et al. Proc Natl Acad Sci U S A, 2004 Jun 22. PMID 15169958, Free PMC Article
    2. Fengshi Liuhe Decoction treatment for rheumatoid arthritis via the Fzd6/NF-κB signaling axis. Zhou F, et al. Gene, 2024 Aug 20. PMID 38710294
    3. Order from disorder: Self-organization in mammalian hair patterning. Wang Y, et al. Proc Natl Acad Sci U S A, 2006 Dec 26. PMID 17172440, Free PMC Article
    4. Expression of members of Wnt and Frizzled gene families in the postnatal rat cochlea. Daudet N, et al. Brain Res Mol Brain Res, 2002 Sep 30. PMID 12399112
    5. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. Golan T, et al. J Biol Chem, 2004 Apr 9. PMID 14747478

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fengshi Liuhe Decoction treatment for rheumatoid arthritis via the Fzd6/NF-kappaB signaling axis.
      Title: Fengshi Liuhe Decoction treatment for rheumatoid arthritis via the Fzd6/NF-κB signaling axis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell proliferation in midbrain ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic nail plate morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of body hair planar orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of planar polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within midbrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    frizzled-6
    Names
    frizzled family receptor 6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130536.1 → NP_001124008.1  frizzled-6 precursor

      See identical proteins and their annotated locations for NP_001124008.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HR66, G3V6L1
      Related
      ENSRNOP00000006195.5, ENSRNOT00000006195.7
      Conserved Domains (2) summary
      cd07450
      Location:20 → 146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188 → 508
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      71939916..71971685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594684.3 → XP_017450173.1  frizzled-6 isoform X1

      UniProtKB/TrEMBL
      A6HR66, G3V6L1
      Conserved Domains (2) summary
      cd07450
      Location:20 → 146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188 → 508
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

    2. XM_039078519.1 → XP_038934447.1  frizzled-6 isoform X1

      UniProtKB/TrEMBL
      A6HR66, G3V6L1
      Conserved Domains (2) summary
      cd07450
      Location:20 → 146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188 → 508
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

    3. XM_039078520.1 → XP_038934448.1  frizzled-6 isoform X1

      UniProtKB/TrEMBL
      A6HR66, G3V6L1
      Related
      ENSRNOP00000104505.1, ENSRNOT00000125394.1
      Conserved Domains (2) summary
      cd07450
      Location:20 → 146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188 → 508
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

    4. XM_063263073.1 → XP_063119143.1  frizzled-6 isoform X1

      UniProtKB/TrEMBL
      A6HR66, G3V6L1

    5. XM_017594686.3 → XP_017450175.1  frizzled-6 isoform X1

      UniProtKB/TrEMBL
      A6HR66, G3V6L1
      Conserved Domains (2) summary
      cd07450
      Location:20 → 146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188 → 508
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

    6. XM_063263074.1 → XP_063119144.1  frizzled-6 isoform X2

    7. XM_063263075.1 → XP_063119145.1  frizzled-6 isoform X3

    RNA

    1. XR_005486551.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous