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    Pgrmc2 progesterone receptor membrane component 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361940, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pgrmc2provided by RGD
    Official Full Name
    progesterone receptor membrane component 2provided by RGD
    Primary source
    RGD:1308804
    See related
    EnsemblRapid:ENSRNOG00000014051 AllianceGenome:RGD:1308804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heme binding activity and heme transmembrane transporter activity. Predicted to be involved in adipose tissue development and heme transport. Predicted to be located in nuclear envelope. Predicted to be active in endoplasmic reticulum; glutamatergic synapse; and membrane. Orthologous to human PGRMC2 (progesterone receptor membrane component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 218.2), Heart (RPKM 179.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pgrmc2 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (125996190..126012090, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (124068257..124084155, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (127986106..128002005, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 1B Neighboring gene La ribonucleoprotein 1B like Neighboring gene uncharacterized LOC134485903 Neighboring gene histone H3.v1-like Neighboring gene uncharacterized LOC120100577

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC93874

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding  
    enables heme binding  
    enables heme transmembrane transporter activity  
    enables steroid binding  
    Process Evidence Code Pubs
    involved_in adipose tissue development  
    involved_in adipose tissue development  
    involved_in heme transport  
    Component Evidence Code Pubs
    is_active_in endomembrane system  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in extracellular region  
    is_active_in glutamatergic synapse  
    is_active_in membrane  
    located_in nuclear envelope  
    located_in nuclear envelope  
    is_active_in synapse  

    General protein information

    Preferred Names
    membrane-associated progesterone receptor component 2
    Names
    progesterone membrane binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008374.1NP_001008375.1  membrane-associated progesterone receptor component 2

      See identical proteins and their annotated locations for NP_001008375.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083571
      UniProtKB/Swiss-Prot
      Q5XIU9
      UniProtKB/TrEMBL
      A6II47
      Related
      ENSRNOP00000018796.4, ENSRNOT00000018796.6
      Conserved Domains (1) summary
      pfam00173
      Location:98161
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      125996190..126012090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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