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    Mgat5b alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgat5bprovided by RGD
    Official Full Name
    alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Bprovided by RGD
    Primary source
    RGD:1305188
    See related
    EnsemblRapid:ENSRNOG00000024954 AllianceGenome:RGD:1305188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity and manganese ion binding activity. Predicted to be involved in protein N-linked glycosylation and protein O-linked glycosylation via serine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 44.1), Thymus (RPKM 22.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mgat5b in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102619559..102689023)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (102120757..102190235)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105861734..105932048)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene serine and arginine rich splicing factor 2 Neighboring gene uncharacterized LOC100912002 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene SEC14-like lipid binding 1 Neighboring gene ribosomal protein L12, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX). Alvarez-Manilla G, et al. Glycobiology, 2010 Feb. PMID 19846580, Free PMC Article
    2. Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain. Inamori K, et al. Biochim Biophys Acta, 2006 Apr. PMID 16413118
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
    Names
    N-acetylglucosaminyltranferase VB
    mannoside acetylglucosaminyltransferase 5, isoenzyme B
    mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
    NP_001100538.1
    XP_008766595.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107068.1 → NP_001100538.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

      See identical proteins and their annotated locations for NP_001100538.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6AL18, A6HL04, D3ZRS9
      Conserved Domains (1) summary
      pfam15024
      Location:10 → 601
      Glyco_transf_18; Glycosyltransferase family 18

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102619559..102689023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768373.4 → XP_008766595.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTQ1, A0A8I6A8E1
      Related
      ENSRNOP00000081732.2, ENSRNOT00000096589.2
      Conserved Domains (1) summary
      pfam15024
      Location:184 → 775
      Glyco_transf_18; Glycosyltransferase family 18
    Nucleotide Protein Strain
    Heading Accession and Version

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