Acin1 apoptotic chromatin condensation inducer 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acin1provided by RGD
Official Full Name: apoptotic chromatin condensation inducer 1provided by RGD
Primary source: RGD:1311945
See related: EnsemblRapid:ENSRNOG00000013533 AllianceGenome:RGD:1311945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including apoptotic chromosome condensation; negative regulation of mRNA splicing, via spliceosome; and positive regulation of monocyte differentiation. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of ASAP complex and exon-exon junction complex. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 247.0), Adrenal (RPKM 218.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32072121..32117004, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28102112..28147001, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33288369..33333256, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate increases in the nuclear levels of caspase-activated acinus and DNase and Endonuclease G (a caspase-independent endonuclease) in CA1 and CA3 pyramidal cell nuclei with different temporal patterns following an AMPA-insult.
Title: AMPA-induced excitotoxicity increases nuclear levels of CAD, endonuclease G, and acinus and induces chromatin condensation in rat hippocampal pyramidal neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141273 (e-PCR)
- UniSTS:223269

RH138440 (e-PCR)
- UniSTS:220527

AI073030 (e-PCR)
- UniSTS:245395

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ASAP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ASAP complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apoptotic chromatin condensation inducer in the nucleus

Names: acinus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170468.1 → NP_001163939.1 apoptotic chromatin condensation inducer in the nucleus

Status: VALIDATED

Source sequence(s)

AA925536, AI575776, CA512047, CB744719, CF110347, EV770592, FM029308, FM031419, FM033220, JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I6AU50, E9PST5

Related

ENSRNOP00000018982.4, ENSRNOT00000018982.8

Conserved Domains (3) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:1011 → 1097

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:1165 → 1240

RSB_motif; RNSP1-SAP18 binding (RSB) motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

32072121..32117004 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274245.1 → XP_063130315.1 apoptotic chromatin condensation inducer in the nucleus isoform X16

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274243.1 → XP_063130313.1 apoptotic chromatin condensation inducer in the nucleus isoform X14

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274240.1 → XP_063130310.1 apoptotic chromatin condensation inducer in the nucleus isoform X11

UniProtKB/TrEMBL

A0A8I6AU50

Related

ENSRNOP00000076634.2, ENSRNOT00000109889.2
XM_063274241.1 → XP_063130311.1 apoptotic chromatin condensation inducer in the nucleus isoform X12

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274239.1 → XP_063130309.1 apoptotic chromatin condensation inducer in the nucleus isoform X6

UniProtKB/TrEMBL

A0A8I6AU50
XM_006251960.5 → XP_006252022.1 apoptotic chromatin condensation inducer in the nucleus isoform X10

UniProtKB/TrEMBL

A0A8I5Y5F2, A0A8I6AU50

Conserved Domains (3) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:971 → 1057

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:1125 → 1200

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_063274237.1 → XP_063130307.1 apoptotic chromatin condensation inducer in the nucleus isoform X4

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274242.1 → XP_063130312.1 apoptotic chromatin condensation inducer in the nucleus isoform X13

UniProtKB/TrEMBL

A0A8I6AU50

Related

ENSRNOP00000096887.2, ENSRNOT00000112466.2
XM_006251959.5 → XP_006252021.1 apoptotic chromatin condensation inducer in the nucleus isoform X9

UniProtKB/TrEMBL

A0A8I6AU50

Conserved Domains (3) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:998 → 1084

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:1152 → 1227

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_017599684.3 → XP_017455173.1 apoptotic chromatin condensation inducer in the nucleus isoform X7

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274235.1 → XP_063130305.1 apoptotic chromatin condensation inducer in the nucleus isoform X2

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274238.1 → XP_063130308.1 apoptotic chromatin condensation inducer in the nucleus isoform X5

UniProtKB/TrEMBL

A0A8I6AU50
XM_006251958.5 → XP_006252020.1 apoptotic chromatin condensation inducer in the nucleus isoform X8

UniProtKB/TrEMBL

A0A8I6AU50

Conserved Domains (3) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:999 → 1085

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:1153 → 1228

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_063274236.1 → XP_063130306.1 apoptotic chromatin condensation inducer in the nucleus isoform X3

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274234.1 → XP_063130304.1 apoptotic chromatin condensation inducer in the nucleus isoform X1

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274244.1 → XP_063130314.1 apoptotic chromatin condensation inducer in the nucleus isoform X15

UniProtKB/TrEMBL

A0A8I6AU50
XM_063274247.1 → XP_063130317.1 apoptotic chromatin condensation inducer in the nucleus isoform X20
XM_006251963.4 → XP_006252025.1 apoptotic chromatin condensation inducer in the nucleus isoform X19

Related

ENSRNOP00000090495.1, ENSRNOT00000111598.2

Conserved Domains (2) summary

cd12432
Location:253 → 339

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:407 → 482

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_063274246.1 → XP_063130316.1 apoptotic chromatin condensation inducer in the nucleus isoform X17
XM_039093289.2 → XP_038949217.1 apoptotic chromatin condensation inducer in the nucleus isoform X18

Conserved Domains (2) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

NF033804
Location:680 → 816

Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin