Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Herpud1provided by RGD
Official Full Name: homocysteine inducible ER protein with ubiquitin like domain 1provided by RGD
Primary source: RGD:620818
See related: EnsemblRapid:ENSRNOG00000018796 AllianceGenome:RGD:620818
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sup
Summary: Predicted to enable transmembrane transporter binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in endoplasmic reticulum unfolded protein response; intracellular calcium ion homeostasis; and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in Lewy body core; endoplasmic reticulum quality control compartment; and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 505.1), Heart (RPKM 463.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (10604360..10624168, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (10598411..10609002, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (11046905..11057440, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells.
Title: Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells.
Results showed that expression of HERPUD1 was increased around the hematoma, which indicated that HERPUD1 might involve in the physiological and pathological process during intracerebral hemorrhage; suggested that HERPUD1 was involved in neuronal apoptosis following intracerebral hemorrhage.
Title: Increased expression of HERPUD1 involves in neuronal apoptosis after intracerebral hemorrhage.
Endoplasmic reticulum stress regulator regulates the survival of vascular smooth cells and neointima formation.
Title: New endoplasmic reticulum stress regulator, Gipie, regulates the survival of vascular smooth muscle cells and the neointima formation after vascular injury.
Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress
Title: Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress.

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General gene information

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Markers

Herpud1 (e-PCR), detects polymorphism
- UniSTS:532488

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to ER	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Lewy body core	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum quality control compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Names: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053523.1 → NP_445975.1 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

See identical proteins and their annotated locations for NP_445975.1

Status: PROVISIONAL

Source sequence(s)

AB033771

UniProtKB/TrEMBL

A6JY67, F7F5G8, Q6P739, Q9ESS9

Related

ENSRNOP00000095807.1, ENSRNOT00000110882.2

Conserved Domains (2) summary

cd01790
Location:9 → 87

Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein

smart00213
Location:10 → 86

UBQ; Ubiquitin homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

10604360..10624168 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255133.5 → XP_006255195.3 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1

UniProtKB/TrEMBL

A0A8I6B3C5