Mmp16 matrix metallopeptidase 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mmp16provided by RGD
Official Full Name: matrix metallopeptidase 16provided by RGD
Primary source: RGD:620199
See related: EnsemblRapid:ENSRNOG00000005708 AllianceGenome:RGD:620199
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mt3-mmp
Summary: Predicted to enable metalloaminopeptidase activity; metalloendopeptidase activity; and zinc ion binding activity. Involved in response to odorant. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space and plasma membrane. Orthologous to human MMP16 (matrix metallopeptidase 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 92.7), Lung (RPKM 49.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (36109265..36353252)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (31312280..31556276)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (31568344..31818368)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MMP16 polymorphisms appear to influence not only the pulmonary expression and function of MMP16 but also the risk of bronchopulmonary dysplasia
Title: Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.

Submit: New GeneRIF Correction

General gene information

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Markers

AB021228 (e-PCR)
- UniSTS:163337

AW532313 (e-PCR)
- UniSTS:245571

D5Wox36 (e-PCR)
- UniSTS:239940

BE115606 (e-PCR)
- UniSTS:248183

MMP16_920 (e-PCR)
- UniSTS:277491

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in craniofacial suture morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic cranial skeleton morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in response to odorant	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: matrix metalloproteinase-16

Names: MMP-16; MT-MMP 3; MT3MMP; MTMMP3; membrane-type matrix metalloproteinase 3; membrane-type-3 matrix metalloproteinase

NP_542954.2

EC 3.4.24.-

XP_038966660.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080776.4 → NP_542954.2 matrix metalloproteinase-16 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O35541, O35548

UniProtKB/TrEMBL

A6IIB9, F1M7F5

Related

ENSRNOP00000040229.6, ENSRNOT00000050137.7

Conserved Domains (5) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

36109265..36353252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110732.2 → XP_038966660.1 matrix metalloproteinase-16 isoform X1

Conserved Domains (4) summary

PHA03247
Location:29 → 75

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:77 → 269

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:1 → 28

Peptidase_M10; Matrixin

pfam11857
Location:274 → 344

DUF3377; Domain of unknown function (DUF3377)