Slc26a1 solute carrier family 26 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc26a1provided by RGD
Official Full Name: solute carrier family 26 member 1provided by RGD
Primary source: RGD:620136
See related: EnsemblRapid:ENSRNOG00000000041 AllianceGenome:RGD:620136
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: sat-1
Summary: Enables sulfate:bicarbonate antiporter activity. Involved in sulfate transmembrane transport. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 458.0), Kidney (RPKM 290.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (1180465..1190257)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (1040565..1045851)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (2050805..2056091)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation.
Title: SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.
Gender differences (males > females) in the expression of sat-1 protein in rat liver (and, possibly, kidneys) are caused by the female sex-hormone-driven inhibition at the posttranscriptional level
Title: The liver and kidney expression of sulfate anion transporter sat-1 in rats exhibits male-dominant gender differences.
Elimination of a dileucine motif at position 677/678 resulted in the loss of basolateral sorting, suggesting that this motif is required for sat-1 targeting to the basolateral membrane.
Title: A dileucine motif targets the sulfate anion transporter sat-1 to the basolateral membrane in renal cell lines.
Sat-1 may be responsible for the uptake of inorganic sulfate from the blood into hepatocytes to enable sulfation reactions. In hepatocytes and endothelial cells, sat-1 may also supply sulfate for proteoglycan synthesis.
Title: Localization of the sulfate/anion exchanger in the rat liver.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxalate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oxalate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables solute:inorganic anion antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfate:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxalate transport	ISO Inferred from Sequence Orthology more info
involved_in oxalate transport	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sulfate anion transporter 1

Names: canalicular sulfate transporter; solute carrier family 26 (anion exchanger), member 1; solute carrier family 26 (sulfate transporter), member 1; sulfate/carbonate antiporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022287.2 → NP_071623.2 sulfate anion transporter 1

See identical proteins and their annotated locations for NP_071623.2

Status: PROVISIONAL

Source sequence(s)

BC085735

UniProtKB/Swiss-Prot

P45380

UniProtKB/TrEMBL

A6KPE0, F7EVA2, Q5RKK1

Related

ENSRNOP00000000047.1, ENSRNOT00000000047.4

Conserved Domains (2) summary

cd07042
Location:537 → 682

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:55 → 685

sulP; high affinity sulphate transporter 1