Jag1 jagged canonical Notch ligand 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jag1provided by RGD
Official Full Name: jagged canonical Notch ligand 1provided by RGD
Primary source: RGD:2937
See related: EnsemblRapid:ENSRNOG00000007443 AllianceGenome:RGD:2937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Predicted to be located in adherens junction and apical plasma membrane. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 122.6), Lung (RPKM 89.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (144859453..144894883, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (124406783..124442220, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (130079361..130114781, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Propofol alleviates neuropathic pain in chronic constriction injury rat models via the microRNA-140-3p/Jagged-1 peptide/Notch signaling pathway.
Title: Propofol alleviates neuropathic pain in chronic constriction injury rat models via the microRNA-140-3p/Jagged-1 peptide/Notch signaling pathway.
[Inhibition of the Notch1/Jagged1 pathway promotes homing of bone mesenchymal stem cells to improve asthma in rats].
Title: [Inhibition of the Notch1/Jagged1 pathway promotes homing of bone mesenchymal stem cells to improve asthma in rats].
SNHG16 aggravates chronic constriction injury-induced neuropathic pain in rats via binding with miR-124-3p and miR-141-3p to upregulate JAG1.
Title: SNHG16 aggravates chronic constriction injury-induced neuropathic pain in rats via binding with miR-124-3p and miR-141-3p to upregulate JAG1.
TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway.
Title: TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway.
Immobilization and functionality of JAG-1 on PEGylated islet surfaces were established. When co-cultured with splenocytes, the JAG-1 conjugated islets induced a significant increase in regulatory T cells and regulated the cytokine levels produced by immune cells. JAG-1 immobilization could improve immunoprotection of pancreatic islets by localized modulation of the immune milieu.
Title: Tolerance induction by surface immobilization of Jagged-1 for immunoprotection of pancreatic islets.
Overexpression of Jagged1 ameliorates aged rat-derived endothelial progenitor cell functions and increases its transfusion efficiency for balloon-induced rat arterial injury.
Title: Overexpression of Jagged1 Ameliorates Aged Rat-Derived Endothelial Progenitor Cell Functions and Improves Its Transfusion Efficiency for Rat Balloon-Induced Arterial Injury.
Jagged1/Notch1 signaling pathway is activated in pulmonary microvascular endothelial cells during the pathogenesis of BLM-induced pulmonary fibrosis in rats.
Title: Potential role of the Jagged1/Notch1 signaling pathway in the endothelial-myofibroblast transition during BLM-induced pulmonary fibrosis.
Nerve regeneration and functional rehabilitation in the recombinant rat jagged1/FC chimera group were advanced significantly due to Notch signaling activation.
Title: Effect of active Notch signaling system on the early repair of rat sciatic nerve injury.
Jag1 can attenuate restenosis of vein graft by inducing decreased proliferation and increased apoptosis in vivo.
Title: Soluble Jagged-1 inhibits restenosis of vein graft by attenuating Notch signaling.
Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1.
Title: β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Jag1 (e-PCR), detects polymorphism
- UniSTS:259624

UniSTS:465457 (e-PCR)
- UniSTS:465457

Jag1 (e-PCR), detects polymorphism
- UniSTS:465457

BE116991 (e-PCR)
- UniSTS:248569

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables Notch binding	TAS Traceable Author Statement more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated immunity	IEA Inferred from Electronic Annotation more info
involved_in T cell mediated immunity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in aorta morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in cardiac neural crest cell development involved in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cardiac neural crest cell development involved in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac right ventricle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cardiac right ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cardiac septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell fate determination	NAS Non-traceable Author Statement more info	PubMed
involved_in ciliary body morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ciliary body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in distal tubule development	IEA Inferred from Electronic Annotation more info
involved_in distal tubule development	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion cell development	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion cell development	ISO Inferred from Sequence Orthology more info
involved_in inhibition of neuroepithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inner ear auditory receptor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
involved_in loop of Henle development	IEA Inferred from Electronic Annotation more info
involved_in loop of Henle development	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of an epithelial sheet	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within morphogenesis of an epithelial sheet	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in nephron development	ISO Inferred from Sequence Orthology more info
involved_in nephron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuroendocrine cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuronal stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in podocyte development	IEA Inferred from Electronic Annotation more info
involved_in podocyte development	ISO Inferred from Sequence Orthology more info
involved_in podocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac epithelial to mesenchymal transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pulmonary artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pulmonary artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to muramyl dipeptide	IEA Inferred from Electronic Annotation more info
involved_in response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein jagged-1

Names: jagged 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019147.3 → NP_062020.2 protein jagged-1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P70640, Q63722

UniProtKB/TrEMBL

A6HQK8, G3V710

Related

ENSRNOP00000010638.6, ENSRNOT00000010638.9

Conserved Domains (5) summary

smart00215
Location:863 → 930

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:629 → 665

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:748 → 777

EGF; EGF-like domain

pfam01414
Location:167 → 229

DSL; Delta serrate ligand

pfam07657
Location:32 → 107

MNNL; N-terminus of Notch ligand