Trh thyrotropin releasing hormone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trhprovided by RGD
Official Full Name: thyrotropin releasing hormoneprovided by RGD
Primary source: RGD:3903
See related: EnsemblRapid:ENSRNOG00000011824 AllianceGenome:RGD:3903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: THR; Trf; TRH01; Pro-TRH
Summary: This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The rat proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin, and may be involved in cardiac function in heart failure. Disruption of this gene is associated with hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, May 2013]
Expression: Biased expression in Brain (RPKM 29.7), Testes (RPKM 9.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (126299236..126301762, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (124742111..124777094, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (124110716..124113242, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sex Dimorphic Changes in Trh Gene Methylation and Thyroid-Axis Response to Energy Demands in Maternally Separated Rats.
Title: Sex Dimorphic Changes in Trh Gene Methylation and Thyroid-Axis Response to Energy Demands in Maternally Separated Rats.
TRH in the nucleus accumbens acts downstream to alpha-MSH to decrease food intake in rats.
Title: TRH in the nucleus accumbens acts downstream to α-MSH to decrease food intake in rats.
Differential activating effects of thyrotropin-releasing hormone and its analog taltirelin on motor output to the tongue musculature in vivo.
Title: Differential activating effects of thyrotropin-releasing hormone and its analog taltirelin on motor output to the tongue musculature in vivo.
Intrauterine Zn deficiency favors thyrotropin-releasing hormone-increasing effects on thyrotropin serum levels and induces subclinical hypothyroidism in weaned rats.
Title: Intrauterine Zn Deficiency Favors Thyrotropin-Releasing Hormone-Increasing Effects on Thyrotropin Serum Levels and Induces Subclinical Hypothyroidism in Weaned Rats.
We found that dehydration induced anorexia rats showed increased number of thyrotropin-releasing hormone (TRH) cells in caudal paraventricular hypothalamic nucleus, as well as a decreased percentage of TRH-expressing neurons that co-expressed monocarboxylate transporter-8 mRNA signal.
Title: Mct8 and trh co-expression throughout the hypothalamic paraventricular nucleus is modified by dehydration-induced anorexia in rats.
The results of this study concluded that long-term changes in dietary Zn down-regulate PPII activity
Title: Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency.
Delayed increases in both the median eminence PPII as well as the thyroliberinase activities in fasted male rats may facilitate the maintenance of deep downregulation of the HPT axis function, despite a partial reactivation of TRH expression in the PVN.
Title: Fasting Enhances Pyroglutamyl Peptidase II Activity in Tanycytes of the Mediobasal Hypothalamus of Male Adult Rats.
TGFbeta2 regulates hypothalamic TRH expression through TIEG1 during fetal development.
Title: TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
a specific TRH increase in the left ventricle induced structural changes in the normal heart
Title: Thyrotropin-releasing hormone overexpression induces structural changes of the left ventricle in the normal rat heart.
Trh, Tnxa and Nnat genes were affected according to the degree of memory in male rats.
Title: Memory-related gene expression profile of the male rat hippocampus induced by teeth extraction and occlusal support recovery.

Submit: New GeneRIF Correction See all GeneRIFs (56)

General gene information

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Markers

RH142232 (e-PCR)
- UniSTS:231481

X59387 (e-PCR)
- UniSTS:125812

PMC304098P6 (e-PCR)
- UniSTS:272525

Trh (e-PCR), detects polymorphism
- UniSTS:547476

RH128079 (e-PCR)
- UniSTS:211387

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables thyrotropin-releasing hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyrotropin-releasing hormone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in eating behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in histamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in histamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glutamate secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gamma-aminobutyric acid secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gamma-aminobutyric acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thyrotropin releasing hormone

Names: TSH-releasing factor; pro-thyrotropin-releasing hormone; prothyroliberin; protirelin; thyrotropin-releasing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.