Micu2 mitochondrial calcium uptake 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Micu2provided by RGD
Official Full Name: mitochondrial calcium uptake 2provided by RGD
Primary source: RGD:619739
See related: EnsemblRapid:ENSRNOG00000011168 AllianceGenome:RGD:619739
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Efha1; Smhs2; RGD1309934
Summary: Predicted to enable calcium ion binding activity; calcium ion sensor activity; and protein heterodimerization activity. Predicted to be involved in calcium import into the mitochondrion; cellular response to calcium ion; and mitochondrial calcium ion homeostasis. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Orthologous to human MICU2 (mitochondrial calcium uptake 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 231.6), Kidney (RPKM 226.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (36180413..36262429, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (32064872..32146874, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (38191506..38276159, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.
Title: Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.

Submit: New GeneRIF Correction

General gene information

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Markers

BM390038 (e-PCR)
- UniSTS:260610

RH128425 (e-PCR)
- UniSTS:211733

AU041871 (e-PCR)
- UniSTS:160396

NoName (e-PCR)
- UniSTS:237197

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion sensor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in calcium import into the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	IEA Inferred from Electronic Annotation more info
part_of uniplex complex	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium uptake protein 2, mitochondrial

Names: EF hand domain family A1; EF-hand domain family, member A1; EF-hand domain-containing family member A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134396.2 → NP_599223.2 calcium uptake protein 2, mitochondrial

Status: VALIDATED

Source sequence(s)

AF327513, BQ207114, CV797964, DY317464, EV765275, EX491796

UniProtKB/Swiss-Prot

Q99P63

Related

ENSRNOP00000015233.4, ENSRNOT00000015233.6

Conserved Domains (1) summary

cd16174
Location:173 → 392

EFh_MICU2; EF-hand, calcium binding motif, found in calcium uptake protein 2, mitochondrial (MICU2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

36180413..36262429 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092977.2 → XP_038948905.1 calcium uptake protein 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A0G2K9A1

Related

ENSRNOP00000074918.2, ENSRNOT00000084698.3

Conserved Domains (2) summary

cd15900
Location:157 → 186

EFh_MICU; EF-hand motif [structural motif]

cl28896
Location:157 → 376

EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
XM_039092978.2 → XP_038948906.1 calcium uptake protein 2, mitochondrial isoform X2

Conserved Domains (2) summary

cd15900
Location:86 → 115

EFh_MICU; EF-hand motif [structural motif]

cl28896
Location:86 → 305

EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins