Ugt2a1 UDP glucuronosyltransferase family 2 member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ugt2a1provided by RGD
Official Full Name: UDP glucuronosyltransferase family 2 member A1provided by RGD
Primary source: RGD:69432
See related: EnsemblRapid:ENSRNOG00000064759 AllianceGenome:RGD:69432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ugt2a1p
Summary: Predicted to enable glucuronosyltransferase activity. Predicted to be involved in bile acid metabolic process; cellular glucuronidation; and sensory perception of chemical stimulus. Predicted to be located in membrane. Orthologous to human UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 2.0) See more
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Genomic context

Location:: 14p21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (20797262..20825111)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (20521018..20545934)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (22192970..22217094)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response.
Title: The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables UDP-glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glucuronosyltransferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in bile acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular glucuronidation	IEA Inferred from Electronic Annotation more info
involved_in cellular glucuronidation	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	TAS Traceable Author Statement more info	PubMed
involved_in sensory perception of chemical stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of chemical stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 2A1

Names: UDP glucuronosyltransferase 2 family, polypeptide A1; UDP glycosyltransferase 2 family, polypeptide A1; UDPGT 2A1; UGT-OLF

NP_071564.2

EC 2.4.1.17

XP_038948318.1

EC 2.4.1.17

XP_063129641.1

EC 2.4.1.17

XP_063129642.1

EC 2.4.1.17

XP_063129643.1

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022228.2 → NP_071564.2 UDP-glucuronosyltransferase 2A1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P36510

UniProtKB/TrEMBL

A6KU27

Related

ENSRNOP00000002704.7, ENSRNOT00000002704.8

Conserved Domains (1) summary

pfam00201
Location:21 → 523

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

20797262..20825111

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273572.1 → XP_063129642.1 UDP-glucuronosyltransferase 2A1 isoform X2

UniProtKB/Swiss-Prot

P36510

UniProtKB/TrEMBL

A6KU27
XM_063273573.1 → XP_063129643.1 UDP-glucuronosyltransferase 2A1 isoform X3
XM_039092390.2 → XP_038948318.1 UDP-glucuronosyltransferase 2A1 isoform X1

UniProtKB/TrEMBL

A0A8I6GMC7

Related

ENSRNOP00000097034.1, ENSRNOT00000100605.2

Conserved Domains (1) summary

pfam00201
Location:22 → 524

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
XM_063273571.1 → XP_063129641.1 UDP-glucuronosyltransferase 2A1 isoform X1

UniProtKB/TrEMBL

A0A8I6GMC7