Hpx hemopexin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hpxprovided by RGD
Official Full Name: hemopexinprovided by RGD
Primary source: RGD:62040
See related: EnsemblRapid:ENSRNOG00000018257 AllianceGenome:RGD:62040
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hpxn
Summary: Predicted to enable heme transmembrane transporter activity and metal ion binding activity. Predicted to be involved in heme metabolic process. Predicted to act upstream of or within several processes, including positive regulation of immune effector process; positive regulation of type II interferon-mediated signaling pathway; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be active in extracellular space. Orthologous to human HPX (hemopexin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 20678.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (169344647..169352155, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (159932819..159940327, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (170423558..170431066, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli.
Title: Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli.
Adenoviral transfer of hemopexin gene attenuates oxidative stress and apoptosis in cultured primary cortical neuron cell exposed to blood clot.
Title: Adenoviral transfer of hemopexin gene attenuates oxidative stress and apoptosis in cultured primary cortical neuron cell exposed to blood clot.
Data suggest that apo-hemopexin isolated from plasma exchibits low endogenous levels of tyrosine nitration in the peptide YYCFQGNQFLR in the heme-binding site of human hemopexin, which was similarly nitrated in rabbit and rat hemopexins; heme binding by hemopexin declined as tyrosine nitration proceeded in vitro.
Title: Identification of oxidative modifications of hemopexin and their predicted physiological relevance.
Hemopexin was identified as upregulated protein in the small intestine exposed to indomethacin.
Title: Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin.
intracellular calcium and protein kinase C activation are involved in the regulation of Hpx.
Title: Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells.
hemopexin mRNA was low or undetectable in livers of hypophysectomized rats, however, daily treatment with bovine growth hormone for 10 days restored hemopexin mRNA levels
Title: Identification of hemopexin as a GH-regulated gene.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Bda32 (e-PCR)
- UniSTS:239779

RH127567 (e-PCR)
- UniSTS:210877

RH127844 (e-PCR)
- UniSTS:211154

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme metabolic process	ISO Inferred from Sequence Orthology more info
involved_in heme transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemoglobin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hemopexin

NP_445770.1

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053318.1 → NP_445770.1 hemopexin precursor

See identical proteins and their annotated locations for NP_445770.1

Status: PROVISIONAL

Source sequence(s)

M62642

UniProtKB/Swiss-Prot

P20059, Q5BKB4

UniProtKB/TrEMBL

A6I7J2

Related

ENSRNOP00000024710.2, ENSRNOT00000024710.7

Conserved Domains (1) summary

cd00094
Location:52 → 230

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...