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    Crygc crystallin, gamma C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crygcprovided by RGD
    Official Full Name
    crystallin, gamma Cprovided by RGD
    Primary source
    RGD:2421
    See related
    EnsemblRapid:ENSRNOG00000014950 AllianceGenome:RGD:2421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Len; Cryg; Cryg3
    Summary
    Predicted to be a structural constituent of eye lens. Involved in lens development in camera-type eye. Predicted to be located in cytoplasm and nucleus. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in cataract and cataract 2 multiple types. Orthologous to human CRYGC (crystallin gamma C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 6.5), Kidney (RPKM 3.8) and 2 other tissues See more
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    Genomic context

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    See Crygc in Genome Data Viewer
    Location:
    9q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73945332..73947367, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (66451591..66453626, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71786246..71788281, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552040 Neighboring gene crystallin, gamma D Neighboring gene crystallin, gamma B Neighboring gene crystallin, gamma A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic, age and light mediated effects on crystallin protein expression in the retina. Organisciak D, et al. Photochem Photobiol, 2006 Jul-Aug. PMID 16602829
    2. A nonsense mutation in CRYGC associated with autosomal dominant congenital nuclear cataract in a Chinese family. Yao K, et al. Mol Vis, 2008 Jul 9. PMID 18618005, Free PMC Article
    3. A 6-bp deletion in the Crygc gene leading to a nuclear and radial cataract in the mouse. Graw J, et al. Invest Ophthalmol Vis Sci, 2002 Jan. PMID 11773036
    4. Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene. Moormann RJ, et al. Proc Natl Acad Sci U S A, 1982 Nov. PMID 6294661, Free PMC Article
    5. The gamma-crystallins and human cataracts: a puzzle made clearer. Héon E, et al. Am J Hum Genet, 1999 Nov. PMID 10521291, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of eye lens TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lens development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-crystallin C
    Names
    crystallin, gamma polypeptide 3
    gamma-C-crystallin
    gamma-crystallin 2-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081660.1 → NP_001075129.1  gamma-crystallin C isoform 2

      See identical proteins and their annotated locations for NP_001075129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      M19359
      UniProtKB/Swiss-Prot
      P02529
      UniProtKB/TrEMBL
      F1LQX2
      Related
      ENSRNOP00000020078.6, ENSRNOT00000020078.7
      Conserved Domains (2) summary
      smart00247
      Location:3 → 82
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:89 → 170
      Crystall; Beta/Gamma crystallin

    2. NM_033483.1 → NP_264077.1  gamma-crystallin C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AI717452, BF523642, BG371711
      UniProtKB/TrEMBL
      F1LQX2
      Conserved Domains (2) summary
      smart00247
      Location:3 → 82
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:90 → 171
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      73945332..73947367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02529.4 GenPept UniProtKB/Swiss-Prot:P02529

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials