Asic3 acid sensing ion channel subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asic3provided by RGD
Official Full Name: acid sensing ion channel subunit 3provided by RGD
Primary source: RGD:708578
See related: EnsemblRapid:ENSRNOG00000008380 AllianceGenome:RGD:708578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Accn3
Summary: Enables ligand-gated sodium channel activity. Involved in monoatomic ion transmembrane transport. Acts upstream of or within response to acidic pH and sodium ion transport. Located in perinuclear region of cytoplasm and plasma membrane. Orthologous to human ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 21.6), Thymus (RPKM 9.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (11652946..11657415, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (10760509..10764987, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (7287868..7293295, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vacuolar-ATPase-mediated muscle acidification caused muscular mechanical nociceptive hypersensitivity after chronic stress in rats, which involved extracellular matrix proteoglycan and ASIC3.
Title: Vacuolar-ATPase-mediated muscle acidification caused muscular mechanical nociceptive hypersensitivity after chronic stress in rats, which involved extracellular matrix proteoglycan and ASIC3.
Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.
Title: Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.
ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of Adelta and C fiber sensory neurons that innervate bone.
Title: ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of Aδ and C fiber sensory neurons that innervate bone.
Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3.
Title: Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3.
The Role of Acid-sensing Ion Channel 3 in the Modulation of Tooth Mechanical Hyperalgesia Induced by Orthodontic Tooth Movement.
Title: The Role of Acid-sensing Ion Channel 3 in the Modulation of Tooth Mechanical Hyperalgesia Induced by Orthodontic Tooth Movement.
Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels.
Title: Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels.
Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin.
Title: Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin.
Functional involvement of acid-sensing ion channel 3 in the swallowing reflex in rats.
Title: Functional involvement of acid-sensing ion channel 3 in the swallowing reflex in rats.
Not only C- but also Adelta-fibre nociceptors in the muscle are involved in mechanical hypersensitivity after lengthening contractions, and that acid-sensing ion channel (ASIC)-3 expressed in the thin-fibre nociceptors is responsible for the mechanical hypersensitivity.
Title: Thin-fibre receptors expressing acid-sensing ion channel 3 contribute to muscular mechanical hypersensitivity after exercise.
Exercise pressor reflex in ASIC3 KO rats was significantly lower than the exercise pressor reflex in WT.
Title: Functional knockout of ASIC3 attenuates the exercise pressor reflex in decerebrated rats with ligated femoral arteries.

Submit: New GeneRIF Correction See all GeneRIFs (51)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enterobactin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated sodium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in enterobactin transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to acidic pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to heat	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sour taste	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acid-sensing ion channel 3

Names: DRASIC; acid-sensing (proton-gated) ion channel 3; amiloride-sensitive cation channel 3; dorsal root ASIC; proton gated cation channel DRASIC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173135.2 → NP_775158.1 acid-sensing ion channel 3

See identical proteins and their annotated locations for NP_775158.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

O35240

UniProtKB/TrEMBL

A6K560, A6K562

Related

ENSRNOP00000011300.1, ENSRNOT00000011300.4

Conserved Domains (1) summary

TIGR00859
Location:17 → 516

ENaC; sodium channel transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

11652946..11657415 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008762632.4 → XP_008760854.1 acid-sensing ion channel 3 isoform X4

UniProtKB/TrEMBL

A6K562

Conserved Domains (1) summary

cl02990
Location:17 → 516

ASC; Amiloride-sensitive sodium channel
XM_039107164.2 → XP_038963092.1 acid-sensing ion channel 3 isoform X1

UniProtKB/TrEMBL

A6K562

Conserved Domains (1) summary

cl02990
Location:17 → 547

ASC; Amiloride-sensitive sodium channel
XM_063285655.1 → XP_063141725.1 acid-sensing ion channel 3 isoform X2

UniProtKB/TrEMBL

A6K562
XM_063285654.1 → XP_063141724.1 acid-sensing ion channel 3 isoform X2

UniProtKB/TrEMBL

A6K562

Related

ENSRNOP00000107682.1, ENSRNOT00000165465.1
XM_017592496.3 → XP_017447985.1 acid-sensing ion channel 3 isoform X3

UniProtKB/TrEMBL

A6K559, A6K562

Conserved Domains (1) summary

cl02990
Location:17 → 438

ASC; Amiloride-sensitive sodium channel
XM_063285656.1 → XP_063141726.1 acid-sensing ion channel 3 isoform X5

UniProtKB/TrEMBL

A0A8I5ZRU8