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    C8b complement C8 beta chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C8bprovided by RGD
    Official Full Name
    complement C8 beta chainprovided by RGD
    Primary source
    RGD:2239
    See related
    EnsemblRapid:ENSRNOG00000007639 AllianceGenome:RGD:2239
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in complement activation. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in type II complement component 8 deficiency. Orthologous to human C8B (complement C8 beta chain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1517.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See C8b in Genome Data Viewer
    Location:
    5q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (124763974..124801522)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (119535009..119572565)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (124298269..124338055)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 1 Neighboring gene proline-rich protein MP5 like 1 Neighboring gene uncharacterized LOC134486959 Neighboring gene uncharacterized LOC120102937 Neighboring gene uncharacterized LOC102547236 Neighboring gene uncharacterized LOC120103169 Neighboring gene complement C8 alpha chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection. Nakashima S, et al. J Immunol, 2002 Oct 15. PMID 12370401
    2. CD59 homologue regulates complement-dependent cytolysis of rat Schwann cells. Sawant-Mane S, et al. J Neuroimmunol, 1996 Sep. PMID 8823377
    3. Molecular mapping of SSRs for Pgm1 and C8b in the vicinity of the rat fatty locus. Kershaw EE, et al. Genomics, 1995 May 1. PMID 7665162
    4. Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. Xiong ZQ, et al. J Neurosci, 2003 Feb 1. PMID 12574424, Free PMC Article
    5. Binding of human and rat CD59 to the terminal complement complexes. Lehto T, et al. Immunology, 1997 Jan. PMID 9038722, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement activation, alternative pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of membrane attack complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane attack complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement component C8 beta chain
    Names
    complement component 8 subunit beta
    complement component 8, beta polypeptide
    complement component 8, beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191759.1 → NP_001178688.1  complement component C8 beta chain precursor

      See identical proteins and their annotated locations for NP_001178688.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P55314, Q5EB58
      UniProtKB/TrEMBL
      A0A8I5ZWX9, A6JRT7
      Related
      ENSRNOP00000010100.5, ENSRNOT00000010100.9
      Conserved Domains (3) summary
      smart00209
      Location:547 → 589
      TSP1; Thrombospondin type 1 repeats
      smart00457
      Location:291 → 497
      MACPF; membrane-attack complex / perforin
      pfam00057
      Location:119 → 154
      Ldl_recept_a; Low-density lipoprotein receptor domain class A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      124763974..124801522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109958.2 → XP_038965886.1  complement component C8 beta chain isoform X1

      Conserved Domains (2) summary
      smart00209
      Location:67 → 112
      TSP1; Thrombospondin type 1 repeats
      pfam00057
      Location:119 → 154
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55314.2 GenPept UniProtKB/Swiss-Prot:P55314

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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