Cpa3 carboxypeptidase A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpa3provided by RGD
Official Full Name: carboxypeptidase A3provided by RGD
Primary source: RGD:2390
See related: EnsemblRapid:ENSRNOG00000011181 AllianceGenome:RGD:2390
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of angiotensin levels in blood. Predicted to be located in transport vesicle. Predicted to be active in extracellular space. Orthologous to human CPA3 (carboxypeptidase A3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 82.7), Thymus (RPKM 45.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (104641619..104673253, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (102712483..102744219, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (105016798..105047989, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that ischemic preconditioning protected against reperfusion injury via the mast cell degranulation-mediated release of MC-CPA.
Title: Pivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia-reperfusion injury in rats after ischemic preconditioning.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiotensin levels in blood	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of angiotensin levels in blood	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mast cell carboxypeptidase A

Names: R-CPA; RMC-CP; carboxypeptidase A3, mast cell

NP_062173.1

EC 3.4.17.1

XP_038958908.1

EC 3.4.17.1

XP_038958909.1

EC 3.4.17.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019300.1 → NP_062173.1 mast cell carboxypeptidase A precursor

See identical proteins and their annotated locations for NP_062173.1

Status: VALIDATED

Source sequence(s)

FM101110, U67914

UniProtKB/Swiss-Prot

P21961, P97597

UniProtKB/TrEMBL

A6IHD2, F1M7S4

Related

ENSRNOP00000014970.8, ENSRNOT00000014970.9

Conserved Domains (2) summary

pfam02244
Location:28 → 102

Propep_M14; Carboxypeptidase activation peptide

cl11393
Location:114 → 413

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

104641619..104673253 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102980.2 → XP_038958908.1 mast cell carboxypeptidase A isoform X1

UniProtKB/Swiss-Prot

P21961, P97597

UniProtKB/TrEMBL

A0A8I6GL18

Related

ENSRNOP00000095188.1, ENSRNOT00000100012.2

Conserved Domains (2) summary

pfam02244
Location:32 → 103

Propep_M14; Carboxypeptidase activation peptide

cl11393
Location:114 → 379

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
XM_039102981.2 → XP_038958909.1 mast cell carboxypeptidase A isoform X2

Conserved Domains (2) summary

pfam02244
Location:32 → 103

Propep_M14; Carboxypeptidase activation peptide

cl11393
Location:114 → 327

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins