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    Ltbp4 latent transforming growth factor beta binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ltbp4provided by RGD
    Official Full Name
    latent transforming growth factor beta binding protein 4provided by RGD
    Primary source
    RGD:1307033
    See related
    EnsemblRapid:ENSRNOG00000020871 AllianceGenome:RGD:1307033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in elastic fiber assembly. Predicted to act upstream of or within hormone secretion and transforming growth factor beta receptor signaling pathway. Predicted to be located in collagen-containing extracellular matrix and microfibril. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IC. Orthologous to human LTBP4 (latent transforming growth factor beta binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 290.0), Lung (RPKM 259.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ltbp4 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91727769..91759822, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82600136..82634346, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (84118046..84152095, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NUMB-like, endocytic adaptor protein Neighboring gene ribosomal protein L14, pseudogene 3 Neighboring gene uncharacterized LOC120099779 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene Sh3kbp1 binding protein 1 Neighboring gene spectrin, beta, non-erythrocytic 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Sterner-Kock A, et al. Genes Dev, 2002 Sep 1. PMID 12208849, Free PMC Article
    2. Identification and characterization of a new latent transforming growth factor-beta-binding protein, LTBP-4. Saharinen J, et al. J Biol Chem, 1998 Jul 17. PMID 9660815
    3. Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts. Koli K, et al. Exp Cell Res, 2005 Nov 1. PMID 16157329
    4. Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. Saharinen J, et al. Mol Biol Cell, 2000 Aug. PMID 10930463, Free PMC Article
    5. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Barallobre-Barreiro J, et al. Circulation, 2016 Sep 13. PMID 27559042, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in elastic fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    latent-transforming growth factor beta-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170336.1 → NP_001163807.1  latent-transforming growth factor beta-binding protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZYC9, D4A917
      Related
      ENSRNOP00000028322.4, ENSRNOT00000028322.8
      Conserved Domains (5) summary
      smart00179
      Location:885 → 921
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:842 → 874
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:418 → 453
      TB; TB domain
      pfam07645
      Location:760 → 800
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:575 → 598
      cEGF; Complement Clr-like EGF-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      91727769..91759822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104072.2 → XP_038960000.1  latent-transforming growth factor beta-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYC9
      Conserved Domains (5) summary
      smart00179
      Location:842 → 878
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:679 → 716
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:760 → 800
      EGF_CA; Calcium-binding EGF domain
      pfam00683
      Location:418 → 460
      TB; TB domain
      pfam12662
      Location:575 → 598
      cEGF; Complement Clr-like EGF-like

    2. XM_063283287.1 → XP_063139357.1  latent-transforming growth factor beta-binding protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K588
      Related
      ENSRNOP00000082670.2, ENSRNOT00000113038.2

    3. XM_006228570.5 → XP_006228632.1  latent-transforming growth factor beta-binding protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K588
      Related
      ENSRNOP00000073336.2, ENSRNOT00000081796.3
      Conserved Domains (5) summary
      smart00179
      Location:818 → 854
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:775 → 807
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:351 → 386
      TB; TB domain
      pfam07645
      Location:693 → 733
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:508 → 531
      cEGF; Complement Clr-like EGF-like
    Nucleotide Protein Strain
    Heading Accession and Version

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