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    Mrpl35 mitochondrial ribosomal protein L35 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrpl35provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L35provided by RGD
    Primary source
    RGD:1307065
    See related
    EnsemblRapid:ENSRNOG00000008546 AllianceGenome:RGD:1307065
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MRPL35 (mitochondrial ribosomal protein L35). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 277.2), Muscle (RPKM 242.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl35 in Genome Data Viewer
    Location:
    4q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105424076..105431844, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103865812..103876687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99738792..99749665, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 3A Neighboring gene uncharacterized LOC134486590 Neighboring gene receptor accessory protein 1 Neighboring gene inner membrane mitochondrial protein Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene Pentatricopeptide repeat domain 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein bL35m
    Names
    39S ribosomal protein L35, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106596.1 → NP_001100066.1  large ribosomal subunit protein bL35m

      See identical proteins and their annotated locations for NP_001100066.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A0A8I6GL56, A6IA89
      Related
      ENSRNOP00000095450.1, ENSRNOT00000117127.2
      Conserved Domains (1) summary
      pfam01632
      Location:102 → 161
      Ribosomal_L35p; Ribosomal protein L35

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      105424076..105431844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107316.2 → XP_038963244.1  large ribosomal subunit protein bL35m isoform X1

      Conserved Domains (1) summary
      pfam01632
      Location:88 → 147
      Ribosomal_L35p; Ribosomal protein L35

    2. XM_039107314.2 → XP_038963242.1  large ribosomal subunit protein bL35m isoform X1

      Conserved Domains (1) summary
      pfam01632
      Location:88 → 147
      Ribosomal_L35p; Ribosomal protein L35
    Nucleotide Protein Strain
    Heading Accession and Version

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