Nup93 nucleoporin 93 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nup93provided by RGD
Official Full Name: nucleoporin 93provided by RGD
Primary source: RGD:1311525
See related: EnsemblRapid:ENSRNOG00000018564 AllianceGenome:RGD:1311525
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport; nucleus organization; and positive regulation of SMAD protein signal transduction. Located in nuclear envelope. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 82.5), Spleen (RPKM 60.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (10690154..10793937, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (10684214..10788009, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (11159769..11263980, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription.
Title: Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d19rat36 (e-PCR)
- UniSTS:121386

RH141887 (e-PCR)
- UniSTS:223879

AU025847 (e-PCR)
- UniSTS:114861

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear envelope organization	IEA Inferred from Electronic Annotation more info
involved_in nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear pore complex assembly	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear pore complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear periphery	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear pore complex protein Nup93

Names: 93 kDa nucleoporin; nucleoporin 93kDa; nucleoporin Nup93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011925.1 → NP_001011925.1 nuclear pore complex protein Nup93

See identical proteins and their annotated locations for NP_001011925.1

Status: PROVISIONAL

Source sequence(s)

BC081925

UniProtKB/Swiss-Prot

Q66HC5

UniProtKB/TrEMBL

A6JY69, A6JY70

Conserved Domains (1) summary

pfam04097
Location:220 → 802

Nic96; Nup93/Nic96

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

10690154..10793937 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277858.1 → XP_063133928.1 nuclear pore complex protein Nup93 isoform X1

UniProtKB/Swiss-Prot

Q66HC5

UniProtKB/TrEMBL

A6JY69, A6JY70

Related

ENSRNOP00000025086.6, ENSRNOT00000025086.8
XM_008772282.4 → XP_008770504.1 nuclear pore complex protein Nup93 isoform X2

UniProtKB/TrEMBL

A0A8I5YC20

Conserved Domains (1) summary

pfam04097
Location:97 → 679

Nic96; Nup93/Nic96