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    Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ublcp1provided by RGD
    Official Full Name
    ubiquitin-like domain containing CTD phosphatase 1provided by RGD
    Primary source
    RGD:1310386
    See related
    EnsemblRapid:ENSRNOG00000004477 AllianceGenome:RGD:1310386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310386
    Summary
    Predicted to enable proteasome regulatory particle binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of ATP-dependent activity and regulation of proteasome assembly. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human UBLCP1 (ubiquitin like domain containing CTD phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 281.7), Thymus (RPKM 270.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ublcp1 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (29447081..29462446, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (28945690..28961103, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (30103607..30118945, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene interleukin 12B Neighboring gene GINS complex subunit 4, pseudogene 1 Neighboring gene ring finger protein 145 Neighboring gene uncharacterized LOC120095078

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Guo X, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 21949367, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105972

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome regulatory particle binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome regulatory particle binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteasome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like domain-containing CTD phosphatase 1
    Names
    nuclear proteasome inhibitor UBLCP1
    NP_001014139.1
    NP_001381239.1
    XP_038942223.1
    XP_063125396.1
    XP_063125397.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014117.2 → NP_001014139.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_001014139.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5FWT7
      UniProtKB/TrEMBL
      A0A0H2UHC8, A6HDP3
      Related
      ENSRNOP00000006063.7, ENSRNOT00000006063.9
      Conserved Domains (2) summary
      TIGR02245
      Location:117 → 311
      HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
      cd01813
      Location:3 → 77
      Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins

    2. NM_001394310.1 → NP_001381239.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0H2UHC8
      Conserved Domains (2) summary
      TIGR02245
      Location:107 → 301
      HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
      cd01813
      Location:3 → 77
      Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      29447081..29462446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269326.1 → XP_063125396.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHC8

    2. XM_063269327.1 → XP_063125397.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHC8

    3. XM_039086295.2 → XP_038942223.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform X3

      Conserved Domains (2) summary
      cd01813
      Location:3 → 77
      Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins
      cl21460
      Location:117 → 149
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWT7.1 GenPept UniProtKB/Swiss-Prot:Q5FWT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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