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    Qprt quinolinate phosphoribosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Qprtprovided by RGD
    Official Full Name
    quinolinate phosphoribosyltransferaseprovided by RGD
    Primary source
    RGD:1310309
    See related
    EnsemblRapid:ENSRNOG00000016980 AllianceGenome:RGD:1310309
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables nicotinate-nucleotide diphosphorylase (carboxylating) activity. Involved in NAD biosynthetic process and quinolinate metabolic process. Predicted to be part of catalytic complex. Predicted to be active in cytoplasm. Used to study Huntington's disease. Orthologous to human QPRT (quinolinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 337.4), Kidney (RPKM 190.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Qprt in Genome Data Viewer
    Location:
    1q37
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191148715..191164006, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181718189..181733486, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198544262..198559556, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 16 open reading frame 54 Neighboring gene uncharacterized LOC134483871 Neighboring gene uncharacterized LOC120099934 Neighboring gene uncharacterized LOC134483868 Neighboring gene sialophorin Neighboring gene uncharacterized LOC134483874

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis. Youn HS, et al. Sci Rep, 2016 Jan 25. PMID 26805589, Free PMC Article
    2. The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid. Malik SS, et al. Proteins, 2014 Mar. PMID 24038671
    3. Crystal structure of Sus scrofa quinolinate phosphoribosyltransferase in complex with nicotinate mononucleotide. Youn HS, et al. PLoS One, 2013. PMID 23626766, Free PMC Article
    4. Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. Liu H, et al. J Mol Biol, 2007 Oct 26. PMID 17868694, Free PMC Article
    5. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. Fukuoka SI, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473669

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108807

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in quinolinate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within quinolinate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in quinolinate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in quinolinate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nicotinate-nucleotide pyrophosphorylase [carboxylating]
    Names
    QAPRTase
    QPRTase
    nicotinate-nucleotide pyrophosphorylase
    NP_001009646.1
    XP_006230308.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009646.1 → NP_001009646.1  nicotinate-nucleotide pyrophosphorylase [carboxylating]

      See identical proteins and their annotated locations for NP_001009646.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088177
      UniProtKB/Swiss-Prot
      Q5I0M2
      UniProtKB/TrEMBL
      A0A8I6G1S5, A6I9L4
      Related
      ENSRNOP00000023080.4, ENSRNOT00000023080.7
      Conserved Domains (2) summary
      cd01572
      Location:17 → 284
      QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
      TIGR00078
      Location:21 → 285
      nadC; nicotinate-nucleotide pyrophosphorylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191148715..191164006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230246.5 → XP_006230308.1  nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZY87, A6I9L5
      Related
      ENSRNOP00000100061.1, ENSRNOT00000130722.1
      Conserved Domains (2) summary
      cd01572
      Location:82 → 349
      QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
      TIGR00078
      Location:86 → 350
      nadC; nicotinate-nucleotide pyrophosphorylase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0M2.1 GenPept UniProtKB/Swiss-Prot:Q5I0M2

    Gene LinkOut

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