Tnk2 tyrosine kinase, non-receptor, 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnk2provided by RGD
Official Full Name: tyrosine kinase, non-receptor, 2provided by RGD
Primary source: RGD:1305957
See related: EnsemblRapid:ENSRNOG00000001769 AllianceGenome:RGD:1305957
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of peptidyl-tyrosine phosphorylation; regulation of clathrin-dependent endocytosis; and spermatid development. Predicted to be located in several cellular components, including clathrin-coated pit; cytoophidium; and cytoplasmic vesicle. Predicted to be part of Grb2-EGFR complex. Predicted to be active in plasma membrane; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 96.5), Thymus (RPKM 75.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (81619795..81659074, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (68114725..68154254, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (71348726..71388520, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF037260 (e-PCR)
- UniSTS:180892

RH134491 (e-PCR)
- UniSTS:217771

RH143928 (e-PCR)
- UniSTS:233174

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spermatid development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Grb2-EGFR complex	ISO Inferred from Sequence Orthology more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoophidium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activated CDC42 kinase 1

Names: ACK-1; activated p21cdc42Hs kinase; tyrosine kinase non-receptor protein 2

NP_001008337.1

EC 2.7.10.2

EC 2.7.11.1

XP_017453469.1

EC 2.7.10.2

EC 2.7.11.1

XP_017453470.1

EC 2.7.10.2

EC 2.7.11.1

XP_017453472.2

EC 2.7.10.2

EC 2.7.11.1

XP_017453473.1

EC 2.7.10.2

EC 2.7.11.1

XP_017453474.1

EC 2.7.10.2

EC 2.7.11.1

XP_017453476.1

EC 2.7.10.2

EC 2.7.11.1

XP_017453479.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944232.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944233.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944234.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944235.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944237.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944239.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944240.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944242.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944243.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944244.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944245.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944249.1

EC 2.7.10.2

EC 2.7.11.1

XP_038944250.1

EC 2.7.10.2

EC 2.7.11.1

XP_063126569.1

EC 2.7.10.2

EC 2.7.11.1

XP_063126571.1

EC 2.7.10.2

EC 2.7.11.1

XP_063126572.1

EC 2.7.10.2

EC 2.7.11.1

XP_063126573.1

EC 2.7.10.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008336.1 → NP_001008337.1 activated CDC42 kinase 1

See identical proteins and their annotated locations for NP_001008337.1

Status: PROVISIONAL

Source sequence(s)

BC085825

UniProtKB/Swiss-Prot

Q5U2X5

UniProtKB/TrEMBL

F1M7W9

Related

ENSRNOP00000002411.4, ENSRNOT00000002411.9

Conserved Domains (8) summary

cd09539
Location:6 → 67

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

smart00221
Location:126 → 385

STYKc; Protein kinase; unclassified specificity

cd14274
Location:961 → 1004

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:991 → 1030

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:130 → 387

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:447 → 514

GTPase_binding; GTPase binding

pfam11555
Location:782 → 838

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:395 → 444

SH3_9; Variant SH3 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

81619795..81659074 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088306.2 → XP_038944234.1 activated CDC42 kinase 1 isoform X3

UniProtKB/TrEMBL

A0A8I6A1S7

Related

ENSRNOP00000070836.3, ENSRNOT00000084768.3

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:641 → 1007

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1022 → 1065

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1052 → 1091

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:843 → 899

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
XM_039088307.1 → XP_038944235.1 activated CDC42 kinase 1 isoform X4

UniProtKB/TrEMBL

A0A8I6A1S7

Conserved Domains (8) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:632 → 998

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1013 → 1056

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1043 → 1082

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:145 → 402

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:464 → 529

GTPase_binding; GTPase binding

pfam11555
Location:834 → 890

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:410 → 459

SH3_9; Variant SH3 domain
XM_039088309.1 → XP_038944237.1 activated CDC42 kinase 1 isoform X8

UniProtKB/TrEMBL

A0A8I6A1S7

Conserved Domains (8) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:568 → 985

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1000 → 1043

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1030 → 1069

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:821 → 877

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
XM_039088315.1 → XP_038944243.1 activated CDC42 kinase 1 isoform X19

UniProtKB/TrEMBL

A0A8I6A0G1

Related

ENSRNOP00000107502.1, ENSRNOT00000162050.1

Conserved Domains (6) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:649 → 1027

PHA03247; large tegument protein UL36; Provisional

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:851 → 907

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
XM_039088311.1 → XP_038944239.1 activated CDC42 kinase 1 isoform X10

UniProtKB/TrEMBL

A0A8I6A0G1

Conserved Domains (7) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:649 → 1027

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:1028 → 1067

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:851 → 907

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
XM_039088305.1 → XP_038944233.1 activated CDC42 kinase 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A1S7

Conserved Domains (8) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:649 → 1038

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1027 → 1071

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1058 → 1097

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:851 → 907

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
XM_063270503.1 → XP_063126573.1 activated CDC42 kinase 1 isoform X17

UniProtKB/TrEMBL

F1M7W9
XM_063270501.1 → XP_063126571.1 activated CDC42 kinase 1 isoform X13

UniProtKB/TrEMBL

A0A8I6A1S7
XM_017597984.2 → XP_017453473.1 activated CDC42 kinase 1 isoform X11

UniProtKB/TrEMBL

A0A0G2K2Q7, F1M7W9
XM_063270502.1 → XP_063126572.1 activated CDC42 kinase 1 isoform X16

UniProtKB/TrEMBL

A0A8I6A1S7

Related

ENSRNOP00000101899.1, ENSRNOT00000124433.1
XM_063270499.1 → XP_063126569.1 activated CDC42 kinase 1 isoform X7

UniProtKB/TrEMBL

A0A8I6A1S7
XM_017597980.2 → XP_017453469.1 activated CDC42 kinase 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A1S7

Related

ENSRNOP00000072336.3, ENSRNOT00000085568.3
XM_039088304.2 → XP_038944232.1 activated CDC42 kinase 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A1S7

Conserved Domains (8) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:649 → 1015

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1030 → 1073

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1060 → 1099

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:851 → 907

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
XM_039088321.2 → XP_038944249.1 activated CDC42 kinase 1 isoform X23

UniProtKB/TrEMBL

A6IRQ0

Conserved Domains (4) summary

PHA03247
Location:127 → 493

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:508 → 551

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:538 → 577

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

pfam11555
Location:329 → 385

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
XM_039088316.2 → XP_038944244.1 activated CDC42 kinase 1 isoform X20

UniProtKB/TrEMBL

A0A0G2JYY3

Conserved Domains (7) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:619 → 997

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:998 → 1037

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:821 → 877

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
XM_039088317.2 → XP_038944245.1 activated CDC42 kinase 1 isoform X22

UniProtKB/TrEMBL

A0A0G2JYY3

Conserved Domains (7) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:604 → 982

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:983 → 1022

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:806 → 862

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
XM_017597983.3 → XP_017453472.2 activated CDC42 kinase 1 isoform X9

UniProtKB/TrEMBL

A0A8I6A1S7

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:619 → 995

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:1000 → 1043

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1030 → 1069

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:821 → 877

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
XM_039088312.2 → XP_038944240.1 activated CDC42 kinase 1 isoform X15

UniProtKB/TrEMBL

F1M7W9

Conserved Domains (8) summary

cd09539
Location:30 → 91

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:604 → 970

PHA03247; large tegument protein UL36; Provisional

cd14274
Location:985 → 1028

UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins

cd14328
Location:1015 → 1054

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:154 → 411

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:473 → 538

GTPase_binding; GTPase binding

pfam11555
Location:806 → 862

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:419 → 468

SH3_9; Variant SH3 domain
XM_017597990.2 → XP_017453479.1 activated CDC42 kinase 1 isoform X21

UniProtKB/TrEMBL

A0A8I6A0G1
XM_017597987.2 → XP_017453476.1 activated CDC42 kinase 1 isoform X14

UniProtKB/TrEMBL

F1M7W9
XM_039088314.1 → XP_038944242.1 activated CDC42 kinase 1 isoform X18

UniProtKB/TrEMBL

A0A8I6A0G1

Conserved Domains (7) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

PHA03247
Location:627 → 1005

PHA03247; large tegument protein UL36; Provisional

cd14328
Location:1006 → 1045

UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam11555
Location:829 → 885

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain
XM_017597985.3 → XP_017453474.1 activated CDC42 kinase 1 isoform X12

UniProtKB/TrEMBL

F1M7W9
XM_017597981.3 → XP_017453470.1 activated CDC42 kinase 1 isoform X6

UniProtKB/TrEMBL

A0A8I6A1S7
XM_039088322.2 → XP_038944250.1 activated CDC42 kinase 1 isoform X24

Conserved Domains (4) summary

cd09539
Location:38 → 99

SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases

cd05040
Location:162 → 419

PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

pfam09027
Location:481 → 546

GTPase_binding; GTPase binding

pfam14604
Location:427 → 476

SH3_9; Variant SH3 domain