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    Sccpdh saccharopine dehydrogenase (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305021, updated on 9-Dec-2024

    Summary

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    Symbol
    Sccpdhprovided by RGD
    Full Name
    saccharopine dehydrogenase (putative)provided by RGD
    Primary source
    RGD:1311440
    See related
    EnsemblRapid:ENSRNOG00000066712 AllianceGenome:RGD:1311440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311440
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in glycolipid biosynthetic process. Predicted to be located in midbody and mitochondrion. Predicted to be active in lipid droplet. Orthologous to human SCCPDH (saccharopine dehydrogenase (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 739.4), Liver (RPKM 508.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sccpdh in Genome Data Viewer
    Location:
    13q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (93932086..93953840)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91400120..91421875)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (97941720..97963474)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transcription factor B2, mitochondrial Neighboring gene uncharacterized LOC108352581 Neighboring gene consortin, connexin sorting protein Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene uncharacterized LOC134481630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Fujimoto Y, et al. Biochim Biophys Acta, 2004 Feb 2. PMID 14741744
    2. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
    3. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
    4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    saccharopine dehydrogenase-like oxidoreductase
    Names
    probable saccharopine dehydrogenase
    NP_001014007.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013985.1 → NP_001014007.1  saccharopine dehydrogenase-like oxidoreductase

      See identical proteins and their annotated locations for NP_001014007.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079215
      UniProtKB/Swiss-Prot
      Q6AY30
      UniProtKB/TrEMBL
      A0A8L2QQT2, A6JGF6
      Related
      ENSRNOP00000003791.5, ENSRNOT00000003791.8
      Conserved Domains (1) summary
      COG3268
      Location:1 → 421
      COG3268; Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      93932086..93953840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY30.1 GenPept UniProtKB/Swiss-Prot:Q6AY30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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