Gmppa GDP-mannose pyrophosphorylase A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gmppaprovided by RGD
Full Name: GDP-mannose pyrophosphorylase Aprovided by RGD
Primary source: RGD:1560644
See related: EnsemblRapid:ENSRNOG00000019946 AllianceGenome:RGD:1560644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity and enzyme inhibitor activity. Predicted to be involved in several processes, including negative regulation of nucleobase-containing compound metabolic process; negative regulation of phosphorus metabolic process; and negative regulation of small molecule metabolic process. Predicted to act upstream of or within several processes, including GDP-mannose biosynthetic process; motor behavior; and protein glycosylation. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 145.3), Kidney (RPKM 111.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (84375373..84382917)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76926724..76934274)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82632267..82639811)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128732 (e-PCR)
- UniSTS:212040

D9Mco51 (e-PCR)
- UniSTS:518495

D9Mco52 (e-PCR)
- UniSTS:518562

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
NOT enables mannose-1-phosphate guanylyltransferase (GTP) activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within GDP-mannose biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within GDP-mannose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GDP-mannose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cognition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in motor behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor behavior	ISO Inferred from Sequence Orthology more info
involved_in muscle organ morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nucleobase-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small molecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of small molecule metabolic process	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in telencephalon development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GDP-mannose pyrophosphorylase complex	IEA Inferred from Electronic Annotation more info
part_of GDP-mannose pyrophosphorylase complex	ISO Inferred from Sequence Orthology more info
part_of GDP-mannose pyrophosphorylase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mannose-1-phosphate guanylyltransferase regulatory subunit alpha; mannose-1-phosphate guanyltransferase alpha

Names: GTP-mannose-1-phosphate guanylyltransferase alpha

NP_001020227.1

EC 2.7.7.13

XP_006245333.1

EC 2.7.7.13

XP_063123697.1

EC 2.7.7.13

XP_063123698.1

EC 2.7.7.13

XP_063123700.1

EC 2.7.7.13

XP_063123701.1

EC 2.7.7.13

XP_063123702.1

EC 2.7.7.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025056.2 → NP_001020227.1 mannose-1-phosphate guanylyltransferase regulatory subunit alpha

See identical proteins and their annotated locations for NP_001020227.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q5XIC1

UniProtKB/TrEMBL

A0A8I5ZKL2, A6JW33

Conserved Domains (3) summary

cd06428
Location:4 → 261

M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase

COG1208
Location:1 → 349

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

cl00160
Location:289 → 355

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
NM_001432721.1 → NP_001419650.1 mannose-1-phosphate guanylyltransferase regulatory subunit alpha

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q5XIC1

UniProtKB/TrEMBL

A0A8I5ZKL2, A6JW33
NM_001432722.1 → NP_001419651.1 mannose-1-phosphate guanylyltransferase regulatory subunit alpha

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q5XIC1

UniProtKB/TrEMBL

A0A8I5ZKL2, A6JW33
NM_001432723.1 → NP_001419652.1 mannose-1-phosphate guanylyltransferase regulatory subunit alpha

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q5XIC1

UniProtKB/TrEMBL

A0A8I5ZKL2, A6JW33
NM_001432724.1 → NP_001419653.1 mannose-1-phosphate guanylyltransferase regulatory subunit alpha

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q5XIC1

UniProtKB/TrEMBL

A0A8I5ZKL2, A6JW33

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

84375373..84382917

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245271.4 → XP_006245333.1 mannose-1-phosphate guanyltransferase alpha isoform X1

Conserved Domains (3) summary

cd06428
Location:4 → 261

M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase

COG1208
Location:1 → 349

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

cl00160
Location:289 → 355

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
XM_063267630.1 → XP_063123700.1 mannose-1-phosphate guanyltransferase alpha isoform X1
XM_063267627.1 → XP_063123697.1 mannose-1-phosphate guanyltransferase alpha isoform X1

Related

ENSRNOP00000027064.3, ENSRNOT00000027064.6
XM_063267628.1 → XP_063123698.1 mannose-1-phosphate guanyltransferase alpha isoform X1
XM_063267632.1 → XP_063123702.1 mannose-1-phosphate guanyltransferase alpha isoform X2

UniProtKB/TrEMBL

A0A8I5ZKL2
XM_063267631.1 → XP_063123701.1 mannose-1-phosphate guanyltransferase alpha isoform X1

UniProtKB/Swiss-Prot

Q5XIC1

UniProtKB/TrEMBL

A0A8I5ZKL2, A6JW33