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    Gpat4 glycerol-3-phosphate acyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpat4provided by RGD
    Official Full Name
    glycerol-3-phosphate acyltransferase 4provided by RGD
    Primary source
    RGD:1310520
    See related
    EnsemblRapid:ENSRNOG00000018077 AllianceGenome:RGD:1310520
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Agpat6; RGD1310520
    Summary
    Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in acyl-CoA metabolic process; phosphatidylcholine biosynthetic process; and triglyceride biosynthetic process. Predicted to act upstream of or within several processes, including acylglycerol metabolic process; glandular epithelial cell maturation; and lactation. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human GPAT4 (glycerol-3-phosphate acyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 464.7), Thymus (RPKM 174.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpat4 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (75515935..75555431)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (68819031..68852903)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (73615949..73649769)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene golgin A7 Neighboring gene GINS complex subunit 4 Neighboring gene NK6 homeobox 3 Neighboring gene ankyrin 1 Neighboring gene uncharacterized LOC120097525

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. Vergnes L, et al. J Lipid Res, 2006 Apr. PMID 16436371, Free PMC Article
    2. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. Beigneux AP, et al. J Lipid Res, 2006 Apr. PMID 16449762, Free PMC Article
    3. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. Chen YQ, et al. J Biol Chem, 2008 Apr 11. PMID 18238778, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glandular epithelial cell maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lactation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mammary gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate acyltransferase 6
    Names
    1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
    lysophosphatidic acid acyltransferase zeta
    putative lysophosphatidic acid acyltransferase
    NP_001041314.1
    XP_038950336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047849.1 → NP_001041314.1  glycerol-3-phosphate acyltransferase 6

      See identical proteins and their annotated locations for NP_001041314.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ480750
      UniProtKB/TrEMBL
      A0A8I6AJ01, A6IW43, B1WBM4, Q0ZFS7
      Related
      ENSRNOP00000092967.1, ENSRNOT00000119896.2
      Conserved Domains (1) summary
      cd07991
      Location:218 → 427
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      75515935..75555431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094408.2 → XP_038950336.1  glycerol-3-phosphate acyltransferase 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT34, A0A8I6AJ01
      Related
      ENSRNOP00000082143.1, ENSRNOT00000099578.2
      Conserved Domains (1) summary
      cd07991
      Location:189 → 397
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    Nucleotide Protein Strain
    Heading Accession and Version

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