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    Atp11a ATPase phospholipid transporting 11A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306600, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp11aprovided by RGD
    Official Full Name
    ATPase phospholipid transporting 11Aprovided by RGD
    Primary source
    RGD:1308688
    See related
    EnsemblRapid:ENSRNOG00000017154 AllianceGenome:RGD:1308688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ua20
    Summary
    Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Predicted to be involved in phospholipid translocation and positive regulation of myotube differentiation. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in Golgi apparatus. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and hypomyelinating leukodystrophy 24. Orthologous to human ATP11A (ATPase phospholipid transporting 11A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 741.0), Lung (RPKM 304.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp11a in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83359884..83469807, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76657752..76767640, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81990340..82100222, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482421 Neighboring gene coagulation factor VII Neighboring gene MCF.2 cell line derived transforming sequence-like Neighboring gene uncharacterized LOC102548949 Neighboring gene uncharacterized LOC134482533 Neighboring gene tubulin gamma complex component 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article
    2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
    3. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane lipid distribution ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase IH
    Names
    ATPase, class VI, type 11A
    UA20 protein-like
    probable phospholipid-transporting ATPase IH
    NP_001100794.2
    NP_001401946.1
    NP_001401947.1
    XP_017455639.1
    XP_017455641.1
    XP_017455642.1
    XP_063131532.1
    XP_063131533.1
    XP_063131534.1
    XP_063131535.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107324.2 → NP_001100794.2  phospholipid-transporting ATPase IH isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IWL3, D4A7K5
      Related
      ENSRNOP00000023163.5, ENSRNOT00000023163.8
      Conserved Domains (7) summary
      TIGR01652
      Location:45 → 1106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102 → 187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477 → 587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:42 → 95
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:854 → 1106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641 → 697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809 → 852
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001415017.1 → NP_001401946.1  phospholipid-transporting ATPase IH isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IWL3
      Related
      ENSRNOP00000102382.1, ENSRNOT00000139085.1

    3. NM_001415018.1 → NP_001401947.1  phospholipid-transporting ATPase IH isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2K8V1, A6IWL3
      Related
      ENSRNOP00000100719.1, ENSRNOT00000152024.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      83359884..83469807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275464.1 → XP_063131534.1  phospholipid-transporting ATPase IH isoform X6

      UniProtKB/TrEMBL
      A6IWL3

    2. XM_017600150.2 → XP_017455639.1  phospholipid-transporting ATPase IH isoform X1

      UniProtKB/TrEMBL
      A6IWL3

    3. XM_063275465.1 → XP_063131535.1  phospholipid-transporting ATPase IH isoform X6

      UniProtKB/TrEMBL
      A6IWL3

    4. XM_017600152.3 → XP_017455641.1  phospholipid-transporting ATPase IH isoform X2

      UniProtKB/TrEMBL
      A6IWL3

    5. XM_017600153.3 → XP_017455642.1  phospholipid-transporting ATPase IH isoform X4

      UniProtKB/TrEMBL
      A6IWL3

    6. XM_063275463.1 → XP_063131533.1  phospholipid-transporting ATPase IH isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZTL7, A6IWL2, A6IWL3
      Related
      ENSRNOP00000074747.3, ENSRNOT00000089447.3

    7. XM_063275462.1 → XP_063131532.1  phospholipid-transporting ATPase IH isoform X3

      UniProtKB/TrEMBL
      A6IWL3
      Related
      ENSRNOP00000081780.2, ENSRNOT00000117454.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144742.1: Suppressed sequence

      Description
      NM_144742.1: This RefSeq was removed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version

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