Emp2 epithelial membrane protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Emp2provided by RGD
Full Name: epithelial membrane protein 2provided by RGD
Primary source: RGD:1359629
See related: EnsemblRapid:ENSRNOG00000002664 AllianceGenome:RGD:1359629
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EMP-2
Summary: Predicted to enable integrin binding activity and protein kinase binding activity. Predicted to be involved in several processes, including bleb assembly; early endosome to late endosome transport; and embryonic process involved in female pregnancy. Predicted to act upstream of or within positive regulation of cell-matrix adhesion. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 1035.7), Heart (RPKM 126.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (5866869..5901533)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (5360073..5394734)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (5433248..5467840)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-340-5p mediates the therapeutic effect of mesenchymal stem cells on corneal neovascularization.
Title: miR-340-5p mediates the therapeutic effect of mesenchymal stem cells on corneal neovascularization.

Submit: New GeneRIF Correction

General gene information

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Markers

D10Rat200 (e-PCR), detects polymorphism
- UniSTS:226311

RH134327 (e-PCR)
- UniSTS:217609

d10mit14 (e-PCR)
- UniSTS:120129

RH143053 (e-PCR)
- UniSTS:232300

BE112998 (e-PCR)
- UniSTS:246257

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin-mediated cell contraction	ISO Inferred from Sequence Orthology more info
involved_in actin-mediated cell contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in bleb assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in caveola assembly	ISO Inferred from Sequence Orthology more info
NOT involved_in caveola assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in embryonic process involved in female pregnancy	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart formation	ISO Inferred from Sequence Orthology more info
involved_in heart formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane raft assembly	ISO Inferred from Sequence Orthology more info
involved_in membrane raft assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in neutrophil migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane raft assembly	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane raft assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in regulation of glomerular filtration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in caveola	ISO Inferred from Sequence Orthology more info
NOT located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: epithelial membrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.