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    Afg3l1 AFG3 (ATPase family gene 3)-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361436, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Afg3l1provided by RGD
    Official Full Name
    AFG3 (ATPase family gene 3)-like 1provided by RGD
    Primary source
    RGD:1309722
    See related
    EnsemblRapid:ENSRNOG00000026994 AllianceGenome:RGD:1309722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to be part of m-AAA complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 152.3), Kidney (RPKM 117.5) and 9 other tissues See more
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    Genomic context

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    See Afg3l1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68417101..68444260)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51508612..51535773)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56272171..56299323)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene tubulin, beta 3 class III Neighboring gene U5 spliceosomal RNA Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene dysbindin domain containing 1 Neighboring gene growth arrest specific 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cristae formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of m-AAA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AFG3(ATPase family gene 3)-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108456.3 → NP_001101926.3  AFG3(ATPase family gene 3)-like 1

      Status: VALIDATED

      Source sequence(s)
      BC168848, JAXUCZ010000019
      UniProtKB/TrEMBL
      B5DEY1
      Related
      ENSRNOP00000037053.6, ENSRNOT00000030399.8
      Conserved Domains (4) summary
      TIGR01241
      Location:247 → 738
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam00004
      Location:337 → 468
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam01434
      Location:554 → 736
      Peptidase_M41; Peptidase family M41
      pfam06480
      Location:143 → 233
      FtsH_ext; FtsH Extracellular

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      68417101..68444260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278164.1 → XP_063134234.1  AFG3(ATPase family gene 3)-like 1 isoform X1

      UniProtKB/TrEMBL
      B5DEY1
      Related
      ENSRNOP00000105074.1, ENSRNOT00000171726.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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