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    Pigc phosphatidylinositol glycan anchor biosynthesis, class C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pigcprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Cprovided by RGD
    Primary source
    RGD:1311337
    See related
    EnsemblRapid:ENSRNOG00000026497 AllianceGenome:RGD:1311337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in glycosylphosphatidylinositol biosynthesis defect 16. Orthologous to human PIGC (phosphatidylinositol glycan anchor biosynthesis class C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 71.9), Spleen (RPKM 65.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pigc in Genome Data Viewer
    Location:
    13q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (76876894..76879420)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (74343619..74346148)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (79886832..79889305)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481576 Neighboring gene uncharacterized LOC103692015 Neighboring gene similar to human chromosome 1 open reading frame 105 Neighboring gene uncharacterized LOC102554129 Neighboring gene dynamin 3 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the phosphatidylinositol glycan C (PIGC) gene are associated with epilepsy and intellectual disability. Edvardson S, et al. J Med Genet, 2017 Mar. PMID 27694521
    2. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase subunit C
    Names
    PIG-C
    phosphatidylinositol glycan, class C
    phosphatidylinositol-glycan biosynthesis class C protein
    NP_001012207.1
    XP_006250244.1
    XP_006250245.1
    XP_008767887.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012207.1 → NP_001012207.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

      See identical proteins and their annotated locations for NP_001012207.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087080
      UniProtKB/Swiss-Prot
      Q5PQQ4
      UniProtKB/TrEMBL
      A6ID87
      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

    2. NM_001429830.1 → NP_001416759.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5PQQ4
      UniProtKB/TrEMBL
      A6ID87

    3. NM_001429831.1 → NP_001416760.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5PQQ4
      UniProtKB/TrEMBL
      A6ID87

    4. NM_001429832.1 → NP_001416761.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5PQQ4
      UniProtKB/TrEMBL
      A6ID87

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      76876894..76879420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250182.4 → XP_006250244.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

      Related
      ENSRNOP00000094482.1, ENSRNOT00000105154.2
      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

    2. XM_006250183.4 → XP_006250245.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

      Related
      ENSRNOP00000035922.3, ENSRNOT00000035558.6
      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

    3. XM_008769665.4 → XP_008767887.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQQ4.1 GenPept UniProtKB/Swiss-Prot:Q5PQQ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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